{"id":"W1971350805","doi":"10.1016/j.molimm.2009.05.018","title":"Autoimmune forms of thrombotic micorangiopathy and membranoproliferative glomerulonephritis: Indications for a disease spectrum and common pathogenic principles","year":2009,"lang":"en","type":"review","venue":"Molecular Immunology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Kidneeds","keywords":"Membranoproliferative glomerulonephritis; Thrombotic thrombocytopenic purpura; Autoantibody; Immunology; Atypical hemolytic uremic syndrome; Alternative complement pathway; Complement system; ADAMTS13; Factor H; Von Willebrand factor; Microangiopathic hemolytic anemia; Glomerulonephritis; Rituximab; Autoimmunity; Complement factor B; C3-convertase; Medicine; Immune system; Antibody; Kidney; Platelet; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005739286,0.001356444,0.002309825,0.002428983,0.0002742713,0.0009856373,0.001203281,0.001503642,0.002078713],"category_scores_gemma":[0.0006224948,0.0003063202,0.0005434855,0.002352897,0.0008783521,0.001726226,0.0008122091,0.002452562,0.001724585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00052213,"about_ca_system_score_gemma":0.0008759947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000589959,"about_ca_topic_score_gemma":0.001280611,"domain_scores_codex":[0.9997769,0.00003075075,0.00004412229,0.00004164451,0.00007979121,0.00002693656],"domain_scores_gemma":[0.9996181,0.0001381679,0.00005978151,0.00001117798,0.0001095416,0.0000631906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002581568,0.0001067896,0.0004454793,0.009670679,0.0001162006,0.001945347,0.0000699603,0.0003242308,0.003314377,0.003620178,0.06278013,0.9173484],"study_design_scores_gemma":[0.0001057967,0.0001286841,0.001491516,0.00198659,0.0001623186,0.01432922,0.00008527411,0.0001480579,0.0005047492,0.002441957,0.978572,0.00004377992],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001553642,0.9976672,0.0003134191,0.0002749262,0.0006776573,0.000005173742,0.00001193463,0.000009734483,0.000884613],"genre_scores_gemma":[0.001184646,0.9955972,0.0006562598,0.0004774593,0.001272164,0.000008445739,0.00005002143,0.00000257048,0.0007512968],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002428983,"threshold_uncertainty_score":0.006953955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02422631472953343,"score_gpt":0.2940294114358614,"score_spread":0.269803096706328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}