{"id":"W1971350805","doi":"10.1016/j.molimm.2009.05.018","title":"Autoimmune forms of thrombotic micorangiopathy and membranoproliferative glomerulonephritis: Indications for a disease spectrum and common pathogenic principles","year":2009,"lang":"en","type":"review","venue":"Molecular Immunology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Kidneeds","keywords":"Membranoproliferative glomerulonephritis; Thrombotic thrombocytopenic purpura; Autoantibody; Immunology; Atypical hemolytic uremic syndrome; Alternative complement pathway; Complement system; ADAMTS13; Factor H; Von Willebrand factor; Microangiopathic hemolytic anemia; Glomerulonephritis; Rituximab; Autoimmunity; Complement factor B; C3-convertase; Medicine; Immune system; Antibody; Kidney; Platelet; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000262873,0.0006412918,0.002443358,0.0004642146,0.0002590818,0.00002884289,0.0004552441,0.0005155553,0.0000477137],"category_scores_gemma":[0.000128596,0.0005764067,0.0005415167,0.0002336194,0.0006937009,0.000074082,0.0003455323,0.0004023321,0.00001963835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007828765,"about_ca_system_score_gemma":0.000338437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002276738,"about_ca_topic_score_gemma":0.00001551018,"domain_scores_codex":[0.9967837,0.0006306644,0.001209099,0.0007419312,0.00005983988,0.0005747215],"domain_scores_gemma":[0.9978626,0.0003128515,0.0008708082,0.0008248365,0.00006958855,0.00005931859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007337577,0.001697498,0.0007226526,0.03583412,0.01109797,0.0001488745,0.0007674819,0.00000186576,0.02846869,0.1013281,0.000116286,0.8190827],"study_design_scores_gemma":[0.01213436,0.004295239,0.02931527,0.03152158,0.0203553,0.002919521,0.0004458052,0.00001829884,0.002325672,0.02178694,0.870538,0.004344008],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01460837,0.9801513,0.0002494804,0.0001251459,0.000194417,0.003378262,0.001184438,0.00007601765,0.00003259139],"genre_scores_gemma":[0.06688764,0.9297692,0.0001362548,0.00004887551,0.00001344254,0.0009319359,0.002055117,0.00007481503,0.00008270606],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8704217,"threshold_uncertainty_score":0.9996687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02422631472953343,"score_gpt":0.2940294114358614,"score_spread":0.269803096706328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}