{"id":"W1971357333","doi":"10.1006/excr.2002.5526","title":"The p53 Stabilizing Compound CP-31398 Induces Apoptosis by Activating the Intrinsic Bax/Mitochondrial/Caspase-9 Pathway","year":2002,"lang":"en","type":"article","venue":"Experimental Cell Research","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Vancouver Hospital and Health Sciences Centre","funders":"","keywords":"Apoptosis; Biology; Cytochrome c; Mitochondrion; Bcl-2-associated X protein; Caspase; Cell biology; Programmed cell death; Cell cycle; Intrinsic apoptosis; Cell cycle checkpoint; Mitochondrial apoptosis-induced channel; Cell; Molecular biology; Caspase 3; Cancer research; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000164854,0.0005131754,0.000465617,0.0004530643,0.0003500206,0.0002788795,0.0002592976,0.0003918036,0.002130954],"category_scores_gemma":[0.0002546216,0.000155605,0.0002634593,0.0003579324,0.0003148333,0.0003397982,0.000196577,0.0013771,0.0005077917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002906687,"about_ca_system_score_gemma":0.0004815306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002626479,"about_ca_topic_score_gemma":0.0004815632,"domain_scores_codex":[0.9998505,0.00001962078,0.00001361611,0.00001826041,0.00004533322,0.00005275382],"domain_scores_gemma":[0.9998749,0.00002855459,0.0000337912,0.00002291985,0.00001371293,0.0000261293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002689353,0.0003771719,0.0005014922,0.0001170611,0.0000250261,0.0002961092,0.00002360539,0.0003249779,0.9815699,0.0005529898,0.0005106064,0.0130117],"study_design_scores_gemma":[0.0002544907,0.001565791,0.002360297,0.000008120119,0.00002328856,0.0005826865,0.00001714296,0.0008169295,0.9924233,0.0002206899,0.001721259,0.000005923698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925977,0.001896105,0.002420358,0.0003486564,0.00007290964,0.00003948995,0.0003629097,0.0002481008,0.002013812],"genre_scores_gemma":[0.996996,0.0009490959,0.0008423657,0.00003171205,0.00001897646,0.00002300246,0.0003644481,0.00001293917,0.000761394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002130954,"threshold_uncertainty_score":0.007128775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08152821978607132,"score_gpt":0.3430855701703163,"score_spread":0.261557350384245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}