{"id":"W1971358650","doi":"10.1124/jpet.114.214619","title":"Preclinical Characterization of Signal Transducer and Activator of Transcription 3 Small Molecule Inhibitors for Primary and Metastatic Brain Cancer Therapy","year":2014,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Cancer Institute; U.S. Public Health Service","keywords":"STAT3; STAT protein; Cancer research; STAT1; In vivo; Melanoma; Glioma; Activator (genetics); Pharmacology; STAT5; Biology; Medicine; Phosphorylation; Cell biology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005180864,0.0006540075,0.0006616492,0.00063746,0.0002890413,0.0005780358,0.0005169567,0.0002986182,0.004001133],"category_scores_gemma":[0.0003587093,0.0002553098,0.0004703023,0.0003681075,0.0003236382,0.0004369515,0.0001214119,0.001255691,0.0007016673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006946854,"about_ca_system_score_gemma":0.001168197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001669324,"about_ca_topic_score_gemma":0.005508943,"domain_scores_codex":[0.9998232,0.0000338681,0.000008501015,0.00001973682,0.00004358491,0.000071182],"domain_scores_gemma":[0.9998541,0.00002531819,0.00002783212,0.00001176219,0.0000363574,0.00004453111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009365894,0.008921794,0.0009342543,0.0005926247,0.0002490185,0.0002059754,0.0001322832,0.004324701,0.9125907,0.001236833,0.003984014,0.05746191],"study_design_scores_gemma":[0.005784136,0.1135693,0.006577879,0.00008250504,0.0007190936,0.000709433,0.0001778398,0.006341816,0.8417125,0.0005784762,0.02369776,0.00004924454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764001,0.008464782,0.005770782,0.0005620356,0.0002025379,0.001388653,0.002367207,0.0001794948,0.00466446],"genre_scores_gemma":[0.9786326,0.008162403,0.003641441,0.0001945985,0.00007017622,0.0009330774,0.002848692,0.00004526965,0.005471739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004001133,"threshold_uncertainty_score":0.01338518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05984025138257387,"score_gpt":0.3773507981528857,"score_spread":0.3175105467703118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}