{"id":"W1971379334","doi":"10.1021/jm800125a","title":"Improvement of<i>meta</i>-tetra(Hydroxyphenyl)chlorin-Like Photosensitizer Selectivity with Folate-Based Targeted Delivery. Synthesis and in Vivo Delivery Studies","year":2008,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre d'expertise et de recherche en infrastructures urbaines","funders":"","keywords":"Photosensitizer; Chlorin; Chemistry; Photodynamic therapy; Folate receptor; In vivo; Conjugate; Selectivity; Biophysics; Cancer research; Biochemistry; Photochemistry; Cancer cell; Cancer; Organic chemistry; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002331754,0.0003349562,0.0002421518,0.000148318,0.0001076132,0.0001925948,0.0002605829,0.0003387289,0.0008722769],"category_scores_gemma":[0.000280752,0.000163274,0.0001708788,0.0001144408,0.000176544,0.0002846799,0.0001276335,0.0003396295,0.0002673479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004599015,"about_ca_system_score_gemma":0.0001787372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007391308,"about_ca_topic_score_gemma":0.0006223423,"domain_scores_codex":[0.9998689,0.00003068172,0.000008749528,0.00003805366,0.00002696675,0.00002677731],"domain_scores_gemma":[0.9998362,0.00004066695,0.00007134774,0.00001229906,0.00002073809,0.00001868131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003886758,0.000007366945,0.00002392672,0.00001747427,0.00000150212,0.000009578098,0.000004834836,0.00004510267,0.9991781,0.00003679937,0.00001198827,0.0006244767],"study_design_scores_gemma":[0.000004960698,0.0001290324,0.0001942006,9.965433e-7,0.000004926606,0.00008621215,0.000001355109,0.0002127196,0.9987462,0.000004666566,0.0006131632,0.000001486633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829411,0.001845808,0.01259992,0.0001174081,0.00001856632,0.00008187909,0.0001508644,0.0001986053,0.002045869],"genre_scores_gemma":[0.9893666,0.001091497,0.007767018,0.00004906657,0.000009629916,0.00002908349,0.0001606942,0.0000397487,0.001486708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008722769,"threshold_uncertainty_score":0.003336787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02362420844915836,"score_gpt":0.2700818399322914,"score_spread":0.246457631483133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}