{"id":"W1971379334","doi":"10.1021/jm800125a","title":"Improvement of<i>meta</i>-tetra(Hydroxyphenyl)chlorin-Like Photosensitizer Selectivity with Folate-Based Targeted Delivery. Synthesis and in Vivo Delivery Studies","year":2008,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre d'expertise et de recherche en infrastructures urbaines","funders":"","keywords":"Photosensitizer; Chlorin; Chemistry; Photodynamic therapy; Folate receptor; In vivo; Conjugate; Selectivity; Biophysics; Cancer research; Biochemistry; Photochemistry; Cancer cell; Cancer; Organic chemistry; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009072968,0.0003465042,0.001481819,0.0002084402,0.00009908519,0.00000504114,0.0001382113,0.0001117825,0.0000797121],"category_scores_gemma":[0.0005314194,0.0002303751,0.000226175,0.0003737054,0.0006415723,0.0001111988,0.00005798218,0.0006917195,2.462017e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003512513,"about_ca_system_score_gemma":0.0005964765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001013013,"about_ca_topic_score_gemma":0.00001994835,"domain_scores_codex":[0.997328,0.00006448662,0.0007443373,0.0002974207,0.001145522,0.0004201795],"domain_scores_gemma":[0.9974164,0.0007544027,0.0005092078,0.0002372138,0.0008067531,0.0002759595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005979063,0.0004248506,0.008678302,0.0008390195,0.003833671,0.002144923,0.0004711743,0.00004275855,0.9767329,6.758241e-8,0.0003524823,0.0005007684],"study_design_scores_gemma":[0.00500477,0.001668713,0.006344004,0.0009122893,0.001332382,0.001315426,0.001144686,0.0001793437,0.9817757,0.00001051354,0.0001042194,0.0002079667],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899041,0.009282248,0.00002049498,0.0003540684,0.0000592359,0.0002590706,0.00001424199,0.00001406419,0.00009249102],"genre_scores_gemma":[0.994413,0.004651385,0.0004553772,0.0001869663,0.0001341727,0.00002192845,0.000001055585,0.00002894944,0.0001071432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005042766,"threshold_uncertainty_score":0.9394422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02362420844915836,"score_gpt":0.2700818399322914,"score_spread":0.246457631483133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}