{"id":"W1971380103","doi":"10.1186/1471-2407-10-515","title":"Antitumour activity of a potent MEK inhibitor RDEA119/BAY 869766 combined with rapamycin in human orthotopic primary pancreatic cancer xenografts","year":2010,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute","keywords":"Surgical oncology; Medicine; Pancreatic cancer; Cancer research; Discovery and development of mTOR inhibitors; Bay; Oncology; Pharmacology; Cancer; Internal medicine; Apoptosis; PI3K/AKT/mTOR pathway; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000144045,0.0004703202,0.0004836748,0.0003614853,0.0001399337,0.0002775815,0.0002390752,0.0001956435,0.001169681],"category_scores_gemma":[0.00007982579,0.0001774014,0.0003449656,0.0003413925,0.0001330209,0.0001418964,0.0001264448,0.0007722246,0.0004138884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000330769,"about_ca_system_score_gemma":0.000345364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001483172,"about_ca_topic_score_gemma":0.002340282,"domain_scores_codex":[0.9999012,0.00001703872,0.000009857587,0.00001718372,0.00002766739,0.00002704576],"domain_scores_gemma":[0.9999125,0.00001609318,0.00002036319,0.0000135874,0.00001002432,0.00002744726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001101522,0.0004853871,0.0002646474,0.00009373037,0.00002556032,0.00005137857,0.00002084174,0.0005972152,0.9922464,0.00003056524,0.0001670811,0.004915691],"study_design_scores_gemma":[0.0002099128,0.005883299,0.004693261,0.000007139562,0.00006561619,0.0002077012,0.00001709471,0.00120065,0.9863837,0.00001129824,0.001314644,0.000005672673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995207,0.001545426,0.0009036724,0.00006931409,0.0000369377,0.00006510221,0.0006279352,0.0001659043,0.001378723],"genre_scores_gemma":[0.9941874,0.001453666,0.001553018,0.00002514154,0.0000128525,0.00004175794,0.001000503,0.00003102565,0.001694703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001483172,"threshold_uncertainty_score":0.003912985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01036864181260302,"score_gpt":0.2491032595514882,"score_spread":0.2387346177388852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}