{"id":"W1971386501","doi":"10.1074/jbc.m609679200","title":"Tautomerism of Histidine 64 Associated with Proton Transfer in Catalysis of Carbonic Anhydrase","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics","keywords":"Tautomer; Histidine; Carbonic anhydrase; Chemistry; Proton; Catalysis; Stereochemistry; Biochemistry; Enzyme; Physics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001661127,0.0001766444,0.0001260379,0.0001192367,0.0001551752,0.000176115,0.00023649,0.0002656494,0.0004789471],"category_scores_gemma":[0.0004019762,0.0001263891,0.0001124324,0.0001090559,0.0003349603,0.0002619689,0.0001071864,0.0002244189,0.00009350421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000702643,"about_ca_system_score_gemma":0.0001434139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00127248,"about_ca_topic_score_gemma":0.001046305,"domain_scores_codex":[0.9999484,0.000009624385,0.000002217274,0.00001741002,0.00001052991,0.00001185925],"domain_scores_gemma":[0.9999021,0.00002670134,0.00003140962,0.000005253786,0.00001176935,0.00002261815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004921888,0.00003190253,0.003461228,0.00005757684,0.00001844236,0.0001857795,0.0001081175,0.001372101,0.9907638,0.0002967554,0.00005953083,0.003152668],"study_design_scores_gemma":[0.00009702683,0.0005606062,0.04415118,0.00001587003,0.00005361515,0.0005610566,0.0001500973,0.0293957,0.9228959,0.001008028,0.001071566,0.0000393806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991628,0.0001129958,0.0004652858,0.00001411798,0.000002284575,0.000001870882,0.000009783333,0.00001348565,0.0002174237],"genre_scores_gemma":[0.9996117,0.00004080414,0.0002228981,0.000003602627,7.856972e-7,0.000001603328,0.00001640177,0.000002722821,0.00009951504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00127248,"threshold_uncertainty_score":0.005098104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01050727061090408,"score_gpt":0.2297566508272001,"score_spread":0.219249380216296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}