{"id":"W1971386958","doi":"10.1038/gt.2009.80","title":"Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice","year":2009,"lang":"nl","type":"article","venue":"Gene Therapy","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of British Columbia Hospital","funders":"Korea Science and Engineering Foundation; Ajou University","keywords":"Neuroprotection; Transplantation; Spinal cord; Neurotrophic factors; Neural stem cell; Vascular endothelial growth factor; Downregulation and upregulation; Medicine; Transgene; Biology; Pathology; Neuroscience; Immunology; Stem cell; Cancer research; Internal medicine; Cell biology; VEGF receptors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003710484,0.0007856524,0.0005499641,0.000782221,0.0003038531,0.0004647966,0.0005063383,0.0006987716,0.001764628],"category_scores_gemma":[0.0002522077,0.0002942636,0.0004263314,0.0002753975,0.0006616092,0.0006516448,0.0002355172,0.001606198,0.0004401177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003887841,"about_ca_system_score_gemma":0.0005827661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001400723,"about_ca_topic_score_gemma":0.002262101,"domain_scores_codex":[0.9997447,0.00002925761,0.00003065457,0.00006095112,0.00005546202,0.00007896895],"domain_scores_gemma":[0.9995525,0.00007250701,0.0001380876,0.00004213925,0.00003455698,0.0001600888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006000816,0.0002490041,0.0001108559,0.00003033722,0.00001067309,0.00007757394,0.0000384313,0.0001009015,0.9970254,0.0001525446,0.00009136051,0.001512775],"study_design_scores_gemma":[0.0001746338,0.001624239,0.002058746,0.00001495908,0.00007168654,0.0002961516,0.00007522012,0.001312622,0.9927457,0.0001412628,0.00147332,0.00001135283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948428,0.0008072767,0.001877585,0.0002554042,0.000117004,0.0000467393,0.0004715755,0.0002188171,0.001362811],"genre_scores_gemma":[0.9852715,0.001017147,0.002655274,0.00009962884,0.00006708914,0.00009640642,0.000723675,0.0000984841,0.009970902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001764628,"threshold_uncertainty_score":0.005903244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05383197718477919,"score_gpt":0.3354291976703994,"score_spread":0.2815972204856202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}