{"id":"W1971386958","doi":"10.1038/gt.2009.80","title":"Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice","year":2009,"lang":"nl","type":"article","venue":"Gene Therapy","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of British Columbia Hospital","funders":"Korea Science and Engineering Foundation; Ajou University","keywords":"Neuroprotection; Transplantation; Spinal cord; Neurotrophic factors; Neural stem cell; Vascular endothelial growth factor; Downregulation and upregulation; Medicine; Transgene; Biology; Pathology; Neuroscience; Immunology; Stem cell; Cancer research; Internal medicine; Cell biology; VEGF receptors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005568434,0.0004185428,0.0006516323,0.0001984463,0.000144257,0.00006784259,0.0002151849,0.0001995726,0.0001488003],"category_scores_gemma":[0.000002790141,0.000363298,0.0001651733,0.0002433512,0.0001953089,0.0002654003,0.0000199566,0.0004543057,0.000006365588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001370204,"about_ca_system_score_gemma":0.0001720877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006168304,"about_ca_topic_score_gemma":0.000087921,"domain_scores_codex":[0.996574,0.0004775159,0.0008469441,0.0006842286,0.0007083394,0.0007089078],"domain_scores_gemma":[0.9987963,0.00006963376,0.0002049345,0.0004173932,0.000110439,0.0004013172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005564902,0.0009860486,0.005277602,0.0001756233,0.00004142236,0.0001599824,0.002149523,0.00006681628,0.9473583,0.000004893412,0.00001910235,0.03819586],"study_design_scores_gemma":[0.01043859,0.005016612,0.4712094,0.0006236875,0.0001894256,0.00001498386,0.000186919,0.001389257,0.5103939,0.00008908364,0.00001027051,0.0004379028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945356,0.002997086,0.00006909307,0.0004554971,0.0001420296,0.001578057,0.0001830089,0.0000300274,0.000009580413],"genre_scores_gemma":[0.9942859,0.004929753,0.00007765694,0.0002266598,0.0001578332,0.00002546821,0.00009535402,0.00005147391,0.0001499065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4659318,"threshold_uncertainty_score":0.9998819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05383197718477919,"score_gpt":0.3354291976703994,"score_spread":0.2815972204856202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}