{"id":"W1971412466","doi":"10.1016/j.lfs.2003.09.016","title":"Continued discovery of ligands for G protein-coupled receptors","year":2003,"lang":"en","type":"review","venue":"Life Sciences","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"","keywords":"Receptor; G protein-coupled receptor; Computational biology; Drug discovery; Biology; Pharmacology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001504111,0.001342848,0.002089719,0.002418987,0.0004688489,0.001628387,0.002010407,0.002376566,0.003009688],"category_scores_gemma":[0.001415979,0.0004341738,0.0005784892,0.002442805,0.001138255,0.00276261,0.001202979,0.003711493,0.003141016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001617167,"about_ca_system_score_gemma":0.001502808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001157159,"about_ca_topic_score_gemma":0.002498656,"domain_scores_codex":[0.9995545,0.00006614102,0.00005308962,0.00007750905,0.0002066047,0.00004216984],"domain_scores_gemma":[0.9993817,0.0002678506,0.00005730029,0.00002429157,0.0001857296,0.00008315203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002256359,0.0001281436,0.0002289687,0.008972355,0.00008410483,0.0007324786,0.00006957311,0.0005104319,0.01021107,0.01293125,0.07700878,0.8888972],"study_design_scores_gemma":[0.00004895235,0.00006648732,0.0002304219,0.0007417266,0.00005578519,0.00107097,0.00003582175,0.00009063693,0.00166211,0.002512913,0.9934682,0.00001598595],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000234416,0.9950311,0.0009719978,0.001147617,0.0009775237,0.00001048664,0.00002392321,0.00002194639,0.001581003],"genre_scores_gemma":[0.0009048445,0.9944862,0.001025265,0.001168718,0.0006725866,0.00001582079,0.00005979821,0.000004975062,0.001661903],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003009688,"threshold_uncertainty_score":0.01173341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03910216614569646,"score_gpt":0.318233325530688,"score_spread":0.2791311593849916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}