{"id":"W1971413445","doi":"10.1038/labinvest.3780323","title":"Inhibitors of Phosphodiesterase Isoforms III or IV Suppress Islet-Cell Nitric Oxide Production","year":2001,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Diabetes Association","keywords":"Rolipram; Nitric oxide; Pentoxifylline; Phosphodiesterase; Forskolin; Endocrinology; Phosphodiesterase inhibitor; Internal medicine; Nitric oxide synthase; Phosphodiesterase 3; Islet; Chemistry; In vivo; Pertussis toxin; Insulinoma; Biology; Insulin; Medicine; Receptor; Biochemistry; Enzyme; G protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003972856,0.0007714168,0.0006694681,0.0005523131,0.000312317,0.0006943995,0.0006884873,0.0004469224,0.001936767],"category_scores_gemma":[0.0005254253,0.0003425718,0.0005587685,0.0003905149,0.0006738728,0.0003524777,0.0003332105,0.001718666,0.0005382738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005559646,"about_ca_system_score_gemma":0.0005696581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001005388,"about_ca_topic_score_gemma":0.001321466,"domain_scores_codex":[0.9996393,0.00006705028,0.00003707044,0.0000488664,0.00007064518,0.0001371274],"domain_scores_gemma":[0.9992369,0.0002127142,0.0001443978,0.0001230994,0.00003140659,0.0002514574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002648731,0.0003579001,0.0002963632,0.00003309247,0.00001728893,0.0001242287,0.00002869257,0.0001545726,0.9936936,0.0002604126,0.0001751079,0.002209943],"study_design_scores_gemma":[0.0002070437,0.0009654693,0.001349713,0.000004060374,0.00002874382,0.0001432929,0.00004076,0.0008499778,0.9953443,0.00007826424,0.0009828014,0.00000546822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929173,0.001303475,0.002111595,0.0002448405,0.000236342,0.00005108877,0.0003801239,0.0001810675,0.002574147],"genre_scores_gemma":[0.991725,0.0008686089,0.002074786,0.0001380094,0.00008392069,0.0001071249,0.0005798045,0.00006359847,0.004359133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001936767,"threshold_uncertainty_score":0.006479144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009721613682962217,"score_gpt":0.218958422404693,"score_spread":0.2092368087217308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}