{"id":"W1971413445","doi":"10.1038/labinvest.3780323","title":"Inhibitors of Phosphodiesterase Isoforms III or IV Suppress Islet-Cell Nitric Oxide Production","year":2001,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Diabetes Association","keywords":"Rolipram; Nitric oxide; Pentoxifylline; Phosphodiesterase; Forskolin; Endocrinology; Phosphodiesterase inhibitor; Internal medicine; Nitric oxide synthase; Phosphodiesterase 3; Islet; Chemistry; In vivo; Pertussis toxin; Insulinoma; Biology; Insulin; Medicine; Receptor; Biochemistry; Enzyme; G protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002311391,0.000197383,0.0001686785,0.0001063846,0.0001288728,0.00002500304,0.0001018757,0.0001947984,0.00004106953],"category_scores_gemma":[0.0001484143,0.0001659049,0.00005505687,0.0005248875,0.0001696861,0.00004486737,0.00004086336,0.00009608542,0.00001308675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003583719,"about_ca_system_score_gemma":0.0001699594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003431958,"about_ca_topic_score_gemma":0.00003168689,"domain_scores_codex":[0.9987268,0.00008379987,0.0004086024,0.000367443,0.0002142439,0.0001990677],"domain_scores_gemma":[0.9988788,0.00001181788,0.0002859327,0.0003647865,0.0003474733,0.0001111904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003151982,0.00007827179,0.01190841,0.00005418836,0.00002052631,0.000002384623,0.0001551186,0.0003821688,0.9776577,0.00002255476,0.00909183,0.0003115943],"study_design_scores_gemma":[0.0007569905,0.0001270353,0.009721508,0.00003732379,0.00002702747,0.000009647877,0.0002564849,0.00009612281,0.9670225,0.00006428365,0.02166098,0.0002200664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980606,0.0003635889,0.0003105001,0.0001721574,0.0005024775,0.0003184858,0.00001976194,0.00004185022,0.0002105686],"genre_scores_gemma":[0.9956903,0.0001621862,0.000499689,0.0004086637,0.0003372366,0.00004189537,0.0003247627,0.00002780516,0.002507505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01256915,"threshold_uncertainty_score":0.6765404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009721613682962217,"score_gpt":0.218958422404693,"score_spread":0.2092368087217308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}