{"id":"W1971416176","doi":"10.1002/pro.2165","title":"<i>LacZ</i> β‐galactosidase: Structure and function of an enzyme of historical and molecular biological importance","year":2012,"lang":"en","type":"review","venue":"Protein Science","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":342,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Oxocarbenium; Active site; Stereochemistry; Tetramer; Nucleophile; lac operon; Enzyme; Catalysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003454284,0.001019731,0.001228009,0.001227515,0.0002427274,0.001290192,0.0006440765,0.0006400949,0.001196808],"category_scores_gemma":[0.0003086825,0.0002467409,0.0004092102,0.002361565,0.0008543187,0.001828623,0.000420277,0.001283692,0.001602232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009771098,"about_ca_system_score_gemma":0.0007985107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008349471,"about_ca_topic_score_gemma":0.0007308564,"domain_scores_codex":[0.9998056,0.0000252801,0.00002615496,0.0000496727,0.00007069104,0.00002270082],"domain_scores_gemma":[0.9998575,0.00003632242,0.00002906789,0.000007232706,0.00004825758,0.0000215348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003429706,0.00006870249,0.001188496,0.02251691,0.0001650557,0.0009050306,0.0004987521,0.001316548,0.109266,0.02717807,0.03501548,0.8015379],"study_design_scores_gemma":[0.000003366484,0.00008139041,0.001052225,0.000626309,0.00003827512,0.001296311,0.0000768575,0.00008809219,0.00701458,0.002347404,0.987354,0.00002117049],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001354212,0.9946424,0.00147345,0.0004428328,0.0005805396,0.000004204635,0.00004776871,0.00003692357,0.001417772],"genre_scores_gemma":[0.005985958,0.9892713,0.001527846,0.0005037962,0.0005234971,0.00001121298,0.0002278562,0.00002179271,0.001926717],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001290192,"threshold_uncertainty_score":0.007089496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03200348940257685,"score_gpt":0.2766141656823813,"score_spread":0.2446106762798044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}