{"id":"W1971447557","doi":"10.1183/09031936.00032713","title":"Genetic heterogeneity of asthma phenotypes identified by a clustering approach","year":2013,"lang":"en","type":"article","venue":"European Respiratory Journal","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Bundesamt für Umwelt; Public Health Research Programme; Medical Research Council; Abbott Diagnostics; Merck Sharp and Dohme; Sociedad Española de Neumología y Cirugía Torácica; British Lung Foundation; Norges Forskningsråd; Chinese Society of Clinical Oncology; Centre Hospitalier Régional Universitaire de Montpellier; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Research Centre; Bundesamt für Gesundheit; Astma- och Allergiförbundet; Institut National de la Santé et de la Recherche Médicale; National Institute of Environmental Health Sciences; Lungenliga Schweiz; Vårdalstiftelsen; Eesti Teadusfondi; European Commission; Agence Nationale de la Recherche; National Science Foundation; Imperial College London; McGill University; Deutsche Forschungsgemeinschaft; Asthma and Lung UK; Freiwillige Akademische Gesellschaft; Universitetet i Bergen","keywords":"Asthma; Single-nucleotide polymorphism; Phenotype; Bronchial hyperresponsiveness; Genome-wide association study; Genetic epidemiology; Epidemiology; Medicine; Genetic heterogeneity; Disease; Immunology; Genetics; Biology; Genotype; Respiratory disease; Internal medicine; Gene; Lung","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001556354,0.0004110869,0.0007566257,0.002244857,0.0004862425,0.001049842,0.000576217,0.0004841901,0.001435745],"category_scores_gemma":[0.00442293,0.0002073391,0.0009404003,0.002037593,0.0003503055,0.0002100685,0.0006748231,0.0004195411,0.0003962347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004021353,"about_ca_system_score_gemma":0.0004425932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004878854,"about_ca_topic_score_gemma":0.004715736,"domain_scores_codex":[0.9981668,0.0008962115,0.00009820001,0.0004584994,0.0002446447,0.000135624],"domain_scores_gemma":[0.9985812,0.0006287766,0.0002785811,0.0002882309,0.0001342444,0.00008901991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009671866,0.0001520415,0.9102406,0.0001172637,0.002065425,0.0005304043,0.0006886543,0.006256522,0.01908895,0.001191969,0.0009135151,0.05778745],"study_design_scores_gemma":[0.00009975484,0.0002033994,0.9506183,0.0000333798,0.0004567194,0.001114209,0.0003838512,0.04160715,0.001015904,0.003249167,0.001173808,0.00004436754],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981883,0.0004226342,0.01613059,0.0001074663,0.00001101716,0.00009819849,0.0004055329,0.00008883728,0.0008526281],"genre_scores_gemma":[0.992297,0.00008789419,0.006675207,0.00002045602,0.00001333112,0.00005179721,0.0006539837,0.00001734895,0.0001829121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004878854,"threshold_uncertainty_score":0.009700894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02108402443934276,"score_gpt":0.2536342627541693,"score_spread":0.2325502383148266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}