{"id":"W1971447557","doi":"10.1183/09031936.00032713","title":"Genetic heterogeneity of asthma phenotypes identified by a clustering approach","year":2013,"lang":"en","type":"article","venue":"European Respiratory Journal","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Bundesamt für Umwelt; Public Health Research Programme; Medical Research Council; Abbott Diagnostics; Merck Sharp and Dohme; Sociedad Española de Neumología y Cirugía Torácica; British Lung Foundation; Norges Forskningsråd; Chinese Society of Clinical Oncology; Centre Hospitalier Régional Universitaire de Montpellier; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Research Centre; Bundesamt für Gesundheit; Astma- och Allergiförbundet; Institut National de la Santé et de la Recherche Médicale; National Institute of Environmental Health Sciences; Lungenliga Schweiz; Vårdalstiftelsen; Eesti Teadusfondi; European Commission; Agence Nationale de la Recherche; National Science Foundation; Imperial College London; McGill University; Deutsche Forschungsgemeinschaft; Asthma and Lung UK; Freiwillige Akademische Gesellschaft; Universitetet i Bergen","keywords":"Asthma; Single-nucleotide polymorphism; Phenotype; Bronchial hyperresponsiveness; Genome-wide association study; Genetic epidemiology; Epidemiology; Medicine; Genetic heterogeneity; Disease; Immunology; Genetics; Biology; Genotype; Respiratory disease; Internal medicine; Gene; Lung","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004644004,0.0002358004,0.0003610151,0.0001664385,0.000183945,0.0001006865,0.0002626718,0.00005417438,0.000432824],"category_scores_gemma":[0.00008701947,0.0001852541,0.0002539261,0.0001533468,0.0001616689,0.0001757938,0.0001154364,0.0003589879,0.0002802642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004204225,"about_ca_system_score_gemma":0.0001037907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003838267,"about_ca_topic_score_gemma":5.922843e-7,"domain_scores_codex":[0.9976864,0.0005026874,0.000698862,0.0002962585,0.0004650432,0.0003507913],"domain_scores_gemma":[0.9984803,0.00002119397,0.0003468722,0.0003969024,0.000241511,0.000513173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004827947,0.001504441,0.1653735,0.0006755922,0.0005113708,0.0008649018,0.0006054537,0.0004261748,0.5430434,0.00001149276,0.07113168,0.2153692],"study_design_scores_gemma":[0.003653012,0.001098124,0.9121833,0.0002721519,0.000146004,0.0009156626,0.000414906,0.0004520645,0.008245371,0.00001408618,0.07207946,0.000525809],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821827,0.00409573,0.004748124,0.00002866414,0.0001779767,0.00028734,0.000008108932,0.00004939457,0.008421929],"genre_scores_gemma":[0.9961661,0.00002728522,0.001786746,0.0009830322,0.0005850801,0.000005740272,0.000003047023,0.00007493541,0.0003680752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7468098,"threshold_uncertainty_score":0.7554444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02108402443934276,"score_gpt":0.2536342627541693,"score_spread":0.2325502383148266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}