{"id":"W1971449549","doi":"10.1021/jm0105474","title":"Design and Synthesis of a Novel Series of 1,2-Disubstituted Cyclopentanes as Small, Potent Potentiators of 2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic Acid (AMPA) Receptors","year":2002,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"IDELIX Software (Canada)","funders":"","keywords":"Potentiator; Chemistry; AMPA receptor; Propanoic acid; Stereochemistry; Cyclopentanes; Isoxazole; Receptor; Lead compound; Structure–activity relationship; Ionotropic effect; Glutamate receptor; Biochemistry; Pharmacology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001124756,0.0005006524,0.0003099198,0.0001841108,0.0001262707,0.0002110774,0.0003248125,0.0002048293,0.001629354],"category_scores_gemma":[0.0001190553,0.0001674572,0.0002023246,0.000168421,0.000150833,0.0002692978,0.0001671251,0.0004257719,0.0005585369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002154386,"about_ca_system_score_gemma":0.0003552477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003791389,"about_ca_topic_score_gemma":0.001084644,"domain_scores_codex":[0.999944,0.000007985368,0.000007311166,0.00001074533,0.00001131731,0.0000187286],"domain_scores_gemma":[0.9999378,0.000004938533,0.00002060015,0.000005661883,0.00001114856,0.00001976186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002969904,0.0001460201,0.0001550716,0.0002236507,0.00001740443,0.0003292931,0.00005062,0.001226894,0.9829937,0.00090596,0.0002751799,0.01337909],"study_design_scores_gemma":[0.000303374,0.003696559,0.001836173,0.00002839158,0.00007568677,0.0007022094,0.00003520282,0.001658997,0.9702244,0.0001928704,0.02120719,0.00003899564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9677637,0.006027815,0.01438371,0.0002923934,0.0001645236,0.0004930473,0.0009715609,0.0002058283,0.009697314],"genre_scores_gemma":[0.9696485,0.007828394,0.01435533,0.0002528385,0.00006409436,0.0002530802,0.001173857,0.00003022333,0.006393726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001629354,"threshold_uncertainty_score":0.005450726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01762054266237383,"score_gpt":0.2351584413557433,"score_spread":0.2175378986933695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}