{"id":"W1971449549","doi":"10.1021/jm0105474","title":"Design and Synthesis of a Novel Series of 1,2-Disubstituted Cyclopentanes as Small, Potent Potentiators of 2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic Acid (AMPA) Receptors","year":2002,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"IDELIX Software (Canada)","funders":"","keywords":"Potentiator; Chemistry; AMPA receptor; Propanoic acid; Stereochemistry; Cyclopentanes; Isoxazole; Receptor; Lead compound; Structure–activity relationship; Ionotropic effect; Glutamate receptor; Biochemistry; Pharmacology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007495967,0.0003390279,0.000886549,0.00009891996,0.00005139785,0.000008133605,0.0004958326,0.0003022666,0.0001462503],"category_scores_gemma":[0.001180405,0.0002836262,0.0002629302,0.0002237215,0.0005182906,0.00002136518,0.0001630809,0.0003158376,7.361232e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003828806,"about_ca_system_score_gemma":0.0001655329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001992884,"about_ca_topic_score_gemma":0.000001555787,"domain_scores_codex":[0.9973386,0.00009824227,0.001319066,0.0003177846,0.0006281539,0.0002981629],"domain_scores_gemma":[0.9971063,0.0001052103,0.001700054,0.0003720038,0.0004839971,0.0002324977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005894077,0.0007295266,0.00176425,0.0004262025,0.0004959111,0.000007831059,0.0001837633,0.00007486463,0.9925733,0.000002124724,0.0003729356,0.002779838],"study_design_scores_gemma":[0.001943312,0.0008792086,0.0003064124,0.0004557786,0.0003873383,0.0007565836,0.00100819,0.00004340216,0.993502,0.000007637619,0.0004821232,0.0002280783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924154,0.005222923,0.001376289,0.0002095786,0.0002184779,0.000188389,0.00001773759,0.000004907557,0.0003463574],"genre_scores_gemma":[0.9904145,0.003023246,0.006002016,0.0000238579,0.0002453254,0.000005987977,0.000007355437,0.00003642919,0.0002412844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004625727,"threshold_uncertainty_score":0.9999616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01762054266237383,"score_gpt":0.2351584413557433,"score_spread":0.2175378986933695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}