{"id":"W1971460933","doi":"10.1158/1078-0432.mechres-a65","title":"Abstract A65: Combinational siRNA silencing of MCL-1 and P-gp enhances the apoptotic response in Human Breast Cancer Cells","year":2012,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Gene silencing; Survivin; Small interfering RNA; Cancer research; Apoptosis; Cancer cell; Biology; Cell; Cancer; Chemistry; Cell culture; Transfection; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001419225,0.0002509452,0.0002814337,0.0002128803,0.0001028612,0.0002412608,0.0001202207,0.0002494805,0.001434162],"category_scores_gemma":[0.00007677798,0.00009873418,0.0002085024,0.0001611658,0.0001118044,0.000114759,0.0001217405,0.0003662912,0.0004295539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001923487,"about_ca_system_score_gemma":0.0001298436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000727246,"about_ca_topic_score_gemma":0.0007515617,"domain_scores_codex":[0.9998475,0.00002043005,0.00001748867,0.00003426123,0.00004905908,0.00003115278],"domain_scores_gemma":[0.9999512,0.000009850074,0.000008437719,0.000007449159,0.00001127335,0.00001166748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001118233,0.00005104029,0.0001017278,0.00003635935,0.000006966344,0.00003282968,0.00001630459,0.00003556285,0.9980253,0.00003403978,0.0001294847,0.001418545],"study_design_scores_gemma":[0.00002321478,0.0006886848,0.001729944,0.00000373873,0.00001956187,0.0002039969,0.00001404134,0.000559764,0.9940995,0.00001157885,0.002643212,0.000002786345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918334,0.002990791,0.002179452,0.000151767,0.00006372626,0.00006528852,0.0003880735,0.0001466293,0.002180854],"genre_scores_gemma":[0.993643,0.0008066623,0.001614072,0.00007464025,0.0000131649,0.00005343488,0.0004929667,0.00001382768,0.003288241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001434162,"threshold_uncertainty_score":0.004797816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1169150641269034,"score_gpt":0.4817236771012256,"score_spread":0.3648086129743222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}