{"id":"W1971471433","doi":"10.1159/000253122","title":"Assessing the Potential Success of Cystic Fibrosis Carrier Screening: Lessons Learned from Tay-Sachs Disease and β-Thalassemia","year":2009,"lang":"en","type":"article","venue":"Public Health Genomics","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Johns Hopkins University","keywords":"Medicine; Population; Thalassemia; Disease; Carrier testing; Cystic fibrosis; Newborn screening; Pediatrics; Environmental health; Internal medicine; Prenatal diagnosis; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04316925,0.0004324163,0.0008493427,0.003849142,0.0006778613,0.00286553,0.001050536,0.001252935,0.0006849255],"category_scores_gemma":[0.1098587,0.0003581673,0.0006534209,0.002810901,0.002311667,0.00560267,0.001484709,0.001264428,0.00008850078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002380778,"about_ca_system_score_gemma":0.006487946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00729746,"about_ca_topic_score_gemma":0.01582438,"domain_scores_codex":[0.9756306,0.01742082,0.002210674,0.0007790097,0.003560598,0.0003981364],"domain_scores_gemma":[0.8231738,0.1533233,0.01014781,0.0009642611,0.01119575,0.001195135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.000243795,0.0002433655,0.2396152,0.02175604,0.001059894,0.002697609,0.05371071,0.001223507,0.0008434595,0.004568161,0.005424188,0.6686141],"study_design_scores_gemma":[0.0002168049,0.002744029,0.5286187,0.06845441,0.003229603,0.008852067,0.2692209,0.007811773,0.002871474,0.03278853,0.07470572,0.0004859719],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4332854,0.4662329,0.006003634,0.08594614,0.0004563509,0.0002121399,0.000196971,0.0000367818,0.007629624],"genre_scores_gemma":[0.8820614,0.1080735,0.006032976,0.002880127,0.0005277154,0.0001120182,0.00006314096,0.000007923719,0.0002412012],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.04316925,"threshold_uncertainty_score":0.2283035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07881343403772445,"score_gpt":0.3943665943674761,"score_spread":0.3155531603297516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}