{"id":"W1971504435","doi":"10.1371/journal.ppat.1003660","title":"The DAF-16/FOXO Transcription Factor Functions as a Regulator of Epidermal Innate Immunity","year":2013,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Yunnan Provincial Science and Technology Department; National Natural Science Foundation of China; National Key Research and Development Program of China; McMaster University","keywords":"Biology; Transcription factor; Cell biology; Innate immune system; Caenorhabditis elegans; Signal transduction; Microbiology; Decay-accelerating factor; NADPH oxidase; Mutant; Reactive oxygen species; Immunology; Immune system; Biochemistry; Gene; Complement system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001347551,0.000179267,0.0001654353,0.00003399013,0.0002753154,0.00003858845,0.0002602612,0.0001627892,0.000181103],"category_scores_gemma":[0.0001172218,0.0001426639,0.0001537428,0.0000783048,0.0001645922,0.000008058508,0.00007470974,0.00014017,0.00007307811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001781692,"about_ca_system_score_gemma":0.00006659708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001551065,"about_ca_topic_score_gemma":0.0000928839,"domain_scores_codex":[0.9988367,0.0001214734,0.0003051175,0.0002574899,0.0001821434,0.0002970652],"domain_scores_gemma":[0.9989295,0.00002362664,0.0001205555,0.0006290775,0.0001963561,0.0001008606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001981533,0.0001052321,0.002209942,0.00001918841,0.000090885,4.611222e-7,0.0004033362,0.00003108313,0.9946399,0.00007294688,0.0006324812,0.001774698],"study_design_scores_gemma":[0.0004631969,0.0004020948,0.04675061,0.00001495191,0.00009737755,0.00001566102,0.0006146083,0.0002940607,0.9406634,0.0007654466,0.009604423,0.0003141527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941531,0.0006053121,0.003648951,0.0003173748,0.0002351907,0.0003489033,0.00009270266,0.00002222936,0.0005762732],"genre_scores_gemma":[0.9979321,0.0002532478,0.0003139112,0.0001703047,0.0001528934,0.00004981484,0.00009353139,0.00003155553,0.001002619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05397652,"threshold_uncertainty_score":0.5817664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01464114101818915,"score_gpt":0.2160835116266835,"score_spread":0.2014423706084943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}