{"id":"W1971523676","doi":"10.1371/journal.pone.0033734","title":"Membrane Fusion and Cell Entry of XMRV Are pH-Independent and Modulated by the Envelope Glycoprotein's Cytoplasmic Tail","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Missouri","keywords":"Gammaretrovirus; Retrovirus; Virology; Viral envelope; Lipid bilayer fusion; Cell fusion; Viral entry; Biology; Syncytium; Cytoplasm; Glycoprotein; Murine leukemia virus; HEK 293 cells; Cell biology; Cell culture; Virus; Molecular biology; Viral replication; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001142882,0.0002158469,0.000174307,0.000104931,0.0001307567,0.0003009498,0.000118121,0.0002124911,0.000605533],"category_scores_gemma":[0.00009250296,0.00008086416,0.0002633249,0.00008991687,0.0001388794,0.0002398556,0.0002412314,0.0003159706,0.0003777074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000199018,"about_ca_system_score_gemma":0.0001172514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002305979,"about_ca_topic_score_gemma":0.0002666334,"domain_scores_codex":[0.9998734,0.0000215724,0.00001242807,0.00001769833,0.00003844846,0.00003645904],"domain_scores_gemma":[0.9999477,0.00001163555,0.00001340516,0.00000832845,0.000008047637,0.0000108873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004758165,0.000008909176,0.0001360401,0.000009700867,0.000001477534,0.00004220489,0.00001140774,0.00001500403,0.9991828,0.00008486627,0.000008485351,0.0004516682],"study_design_scores_gemma":[0.00001003587,0.0002138893,0.009323456,0.00000503474,0.000006469477,0.0004623192,0.00004213237,0.0007000912,0.9875013,0.00006489037,0.001665438,0.00000505593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952778,0.001425778,0.001760944,0.00003600423,0.000007566255,0.00001498459,0.0001878523,0.00002385342,0.001265283],"genre_scores_gemma":[0.9963193,0.0008206392,0.0009183762,0.00002825395,0.000004811233,0.00001963712,0.0005636872,0.00001066934,0.001314569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000605533,"threshold_uncertainty_score":0.002025664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01792824669628015,"score_gpt":0.2248543996185336,"score_spread":0.2069261529222534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}