{"id":"W1971532562","doi":"10.1038/mt.2014.21","title":"Phase 1 Clinical Trial of Intratumoral Reovirus Infusion for the Treatment of Recurrent Malignant Gliomas in Adults","year":2014,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"Oncolytics Biotech; University of Alabama at Birmingham","keywords":"Medicine; Clinical trial; Glioma; Oncology; Cancer research; Internal medicine; Pathology; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001348886,0.001437765,0.001131169,0.0003209705,0.0004161809,0.0005949396,0.0005956296,0.00131378,0.001447556],"category_scores_gemma":[0.0007856183,0.0003722695,0.0008654382,0.0002062352,0.0005454947,0.0004731056,0.0002766209,0.00229532,0.0004091868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006153563,"about_ca_system_score_gemma":0.001222702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006502043,"about_ca_topic_score_gemma":0.001789683,"domain_scores_codex":[0.9996749,0.0001536314,0.00001806871,0.00005113909,0.00003106627,0.00007109398],"domain_scores_gemma":[0.9995279,0.00008185589,0.0001225115,0.00004702243,0.00004770179,0.0001730787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4853665,0.1489593,0.009633712,0.001033439,0.001147801,0.0010935,0.0009360578,0.003880784,0.1494566,0.0006352609,0.005690997,0.1921661],"study_design_scores_gemma":[0.1705469,0.8073025,0.007795208,0.00003134525,0.0001887503,0.0004176142,0.00005255151,0.001142856,0.009886466,0.0001520479,0.002459508,0.00002426707],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932247,0.001120865,0.0009258991,0.0002749283,0.00008442082,0.00307013,0.000375406,0.00009104505,0.0008326555],"genre_scores_gemma":[0.9873478,0.001311895,0.002543979,0.0006526035,0.0001230991,0.004776205,0.001185456,0.00002302612,0.002035861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001447556,"threshold_uncertainty_score":0.007133663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05011960824218846,"score_gpt":0.3974668225247628,"score_spread":0.3473472142825744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}