{"id":"W1971582979","doi":"10.1242/dev.038828","title":"Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2","year":2010,"lang":"en","type":"article","venue":"Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":481,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; Discovery Centre","funders":"Canadian Institutes of Health Research; Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences","keywords":"Trophoblast; Biology; Blastocyst; Embryonic stem cell; Inner cell mass; GATA3; Transcription factor; Stem cell; Cell biology; CDX2; RUNX2; Embryo; Genetics; Placenta; Embryogenesis; Gene; Homeobox; Fetus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002079059,0.0001230366,0.0001272685,0.00008086915,0.00003849312,0.00001117479,0.0000966326,0.0001002079,0.00001172839],"category_scores_gemma":[0.00004218931,0.000116635,0.00001524503,0.00008097247,0.00003191124,0.000002111663,0.0001141834,0.00006292355,0.000006560738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000132407,"about_ca_system_score_gemma":0.0001417258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000974261,"about_ca_topic_score_gemma":0.0003892132,"domain_scores_codex":[0.999134,0.00001395714,0.0002962563,0.0002636535,0.0001142846,0.0001778443],"domain_scores_gemma":[0.9996254,0.000007617116,0.00005527127,0.0001698942,0.00005114735,0.00009065795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004748751,0.00005872146,0.02509787,0.00001590652,0.00001578947,0.000001356427,0.000421148,0.00005888946,0.9303975,0.00002179695,0.00004317826,0.04382038],"study_design_scores_gemma":[0.0002782971,0.00003713507,0.2410712,0.00001323483,0.000001386371,0.000001060334,0.00002902225,0.000006209712,0.7129731,0.000025651,0.04543691,0.0001267303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983801,0.000184422,0.0007581126,0.00006964482,0.00007840234,0.0001693925,0.000001912778,0.000004186821,0.0003538159],"genre_scores_gemma":[0.9303473,0.00004318471,0.06919342,0.00003591636,0.0000223543,0.00003085371,0.00005145325,0.00001092897,0.000264627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2174243,"threshold_uncertainty_score":0.4756238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005914087330131185,"score_gpt":0.2278888029162622,"score_spread":0.221974715586131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}