{"id":"W1971586535","doi":"10.1016/j.bmcl.2008.10.116","title":"2,6,9-Trisubstituted purine derivatives as protein A mimetics for the treatment of autoimmune diseases","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Aptose Biosciences (Canada)","funders":"","keywords":"Chemistry; Purine; Purine metabolism; Purine analogue; Antibody; Biochemistry; Stereochemistry; Enzyme; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001932546,0.0002185104,0.0002252962,0.0002461204,0.0001499133,0.0001712122,0.0003035893,0.0003306372,0.001168697],"category_scores_gemma":[0.0001102682,0.0001272491,0.0001188287,0.0001806365,0.0001403895,0.0001929714,0.0001256431,0.0003672321,0.0002861668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001856384,"about_ca_system_score_gemma":0.0001279597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002121951,"about_ca_topic_score_gemma":0.0005036247,"domain_scores_codex":[0.9999344,0.00002584061,0.000005439834,0.000008252652,0.00001165212,0.00001434469],"domain_scores_gemma":[0.9999607,0.00000928899,0.000009994375,0.000003545969,0.000003551688,0.00001286303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001434599,0.0001940721,0.0002519345,0.0002071235,0.00002834523,0.0005975525,0.00007339501,0.001361259,0.9586657,0.001505127,0.0006662928,0.03501459],"study_design_scores_gemma":[0.0005207229,0.005134177,0.003288911,0.00003720788,0.00009659939,0.001678939,0.00003529853,0.003489348,0.9592924,0.0004278528,0.02595325,0.00004522534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9656583,0.02361653,0.003061883,0.0002857363,0.00018377,0.0000725195,0.0002581538,0.0001994352,0.006663708],"genre_scores_gemma":[0.9868056,0.008123369,0.002281836,0.0001326153,0.00006647571,0.0000442627,0.0001733084,0.00001913062,0.00235344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001168697,"threshold_uncertainty_score":0.003909707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03219205191669177,"score_gpt":0.2938091981328222,"score_spread":0.2616171462161305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}