{"id":"W1971602461","doi":"10.1021/bi061077o","title":"Binding of Polyaminocarboxylate Chelators to the Active-Site Copper Inhibits the GSNO-Reductase Activity but Not the Superoxide Dismutase Activity of Cu,Zn-Superoxide Dismutase","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"","keywords":"Chemistry; Phenylglyoxal; Superoxide dismutase; Glutathione; Dissociation constant; Dismutase; Superoxide; Chelation; Glutathione reductase; Biochemistry; Enzyme; Inorganic chemistry; Arginine; Glutathione peroxidase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002486897,0.0005165607,0.0004210373,0.0001416174,0.0001731121,0.0002292983,0.0004664933,0.0003949209,0.001881575],"category_scores_gemma":[0.0004101669,0.0002651294,0.0002855787,0.0001580864,0.0002660608,0.0001441503,0.0002163474,0.0004704935,0.0007092265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002775039,"about_ca_system_score_gemma":0.0002902724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001492792,"about_ca_topic_score_gemma":0.002192358,"domain_scores_codex":[0.9995116,0.0000726221,0.00005385736,0.0001389144,0.0001375148,0.00008549038],"domain_scores_gemma":[0.9996114,0.00007465837,0.0001262355,0.00006405411,0.00006705628,0.00005661669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001622131,0.00004184612,0.00005517203,0.00003599172,0.000005612212,0.00001461712,0.000008114639,0.00003972963,0.9988459,0.00001847601,0.00007388954,0.0006984488],"study_design_scores_gemma":[0.00001911468,0.000414103,0.001722697,0.000004358974,0.00001131083,0.00004849938,0.000005711008,0.0004633229,0.9946011,0.000009513923,0.002694711,0.000005638829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987578,0.00248853,0.006661518,0.0001782718,0.0002094818,0.0001366147,0.0003472203,0.0001982622,0.002202092],"genre_scores_gemma":[0.9798158,0.001516378,0.009019115,0.0002702501,0.00008840921,0.0002001655,0.001279654,0.00005796873,0.007752232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001881575,"threshold_uncertainty_score":0.006294489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01007658508923615,"score_gpt":0.2438621341055854,"score_spread":0.2337855490163493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}