{"id":"W1971644094","doi":"10.1371/journal.pcbi.1002271","title":"A Density-Dependent Switch Drives Stochastic Clustering and Polarization of Signaling Molecules","year":2011,"lang":"en","type":"article","venue":"PLoS Computational Biology","topic":"Gene Regulatory Network Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Rita Allen Foundation; Welch Foundation; National Science Foundation","keywords":"Cluster analysis; Positive feedback; Cell signaling; Negative feedback; Biological system; Directionality; Physics; Signal transduction; Mechanism (biology); Biophysics; Biology; Statistical physics; Topology (electrical circuits); Computer science; Cell biology; Genetics; Mathematics; Voltage; Artificial intelligence","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007789079,0.000104223,0.000150666,0.00007523201,0.00005242596,0.000005117046,0.00008199087,0.00009705286,0.00001151847],"category_scores_gemma":[0.00003499992,0.0001050278,0.00004380435,0.00006469819,0.00009285276,0.000002964051,0.0001137091,0.00003980229,0.000001780586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005858379,"about_ca_system_score_gemma":0.00003249558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001335554,"about_ca_topic_score_gemma":0.0000151434,"domain_scores_codex":[0.9992768,0.00007497603,0.0002023242,0.0002534253,0.00006965677,0.0001227773],"domain_scores_gemma":[0.9995854,0.00002441079,0.000116092,0.0001007046,0.0001295861,0.00004382461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006106319,0.00006601174,0.0237379,0.00001897809,0.0002647772,0.000001080574,0.0001526265,0.0535692,0.9207258,0.0007830241,0.000003249355,0.0006162743],"study_design_scores_gemma":[0.001838004,0.001209872,0.1098579,0.00008294381,0.0004638671,0.0001103811,0.0003198657,0.3412843,0.5243969,0.01945559,0.00002325795,0.0009571163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6948081,0.0002547238,0.304806,0.00001134333,0.00002113856,0.00005946723,0.000005157088,0.000006236683,0.00002784115],"genre_scores_gemma":[0.9876232,0.000007079073,0.01209868,0.00004926113,0.00004926934,0.000004725982,0.000143642,0.00001110772,0.0000130713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3963289,"threshold_uncertainty_score":0.4282909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01611935900763161,"score_gpt":0.2237520665483821,"score_spread":0.2076327075407505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}