{"id":"W1971648238","doi":"10.1016/j.ejcb.2012.07.001","title":"ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion","year":2012,"lang":"en","type":"article","venue":"European Journal of Cell Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institut Curie; Institute of Cancer Research; Institut national de la recherche scientifique; Institut National Du Cancer; Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale","keywords":"Cortactin; Invadopodia; Cell biology; Acetylation; HDAC6; Extracellular matrix; Endosome; Podosome; Stromal cell; Chemistry; Cell migration; Cancer cell; Matrix metalloproteinase; Biology; Histone deacetylase; Cell; Biochemistry; Cancer research; Histone; Cancer; Cytoskeleton; Intracellular","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001287244,0.0002143691,0.0004272466,0.0001290536,0.00007449712,0.00001466324,0.0001178438,0.00009311525,0.00001123924],"category_scores_gemma":[0.0001156603,0.0001859197,0.00006631239,0.00007185601,0.0004327454,0.00002722175,0.00009160268,0.0002453535,7.899064e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001012309,"about_ca_system_score_gemma":0.0000600138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007026983,"about_ca_topic_score_gemma":0.000004411201,"domain_scores_codex":[0.9980169,0.0006771634,0.0006045979,0.000270626,0.0001255746,0.0003051402],"domain_scores_gemma":[0.998772,0.0001114292,0.0004719916,0.0001770513,0.0001669394,0.0003006256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008652183,0.0001039787,0.006067702,0.000129275,0.00004173157,0.00002151637,0.0003497631,0.00001602502,0.9894497,0.000005236063,0.0001427813,0.002807034],"study_design_scores_gemma":[0.005052434,0.001715375,0.01603547,0.0001056614,0.00007991984,0.001208043,0.0001777675,0.0001550544,0.9734287,0.000003463387,0.001808168,0.0002299299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909425,0.007868029,0.0005263886,0.00009716681,0.00007132942,0.0001774443,0.0000515712,0.000003466323,0.0002621079],"genre_scores_gemma":[0.9974915,0.00159437,0.0005900403,0.00005939123,0.0001666381,8.617164e-7,0.00001746731,0.00003110028,0.00004861569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01602102,"threshold_uncertainty_score":0.7581584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007310393864391466,"score_gpt":0.2257816239770609,"score_spread":0.2184712301126694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}