{"id":"W1971668211","doi":"10.1038/nchembio.559","title":"Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy","year":2011,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":521,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Antibiotics; Antimicrobial; Minocycline; Microbiology; Drug; In vivo; Biology; Anti-Infective Agents; Pharmacology; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007686789,0.0001554717,0.0002303466,0.00003752708,0.00004012216,0.000005421699,0.0001724304,0.0005088961,0.00001477168],"category_scores_gemma":[0.000126611,0.0001273323,0.00008073491,0.00007532482,0.0003408974,0.00000381711,0.0001264438,0.0001952367,0.00000228158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003616128,"about_ca_system_score_gemma":0.00002262954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001015092,"about_ca_topic_score_gemma":0.000001803806,"domain_scores_codex":[0.9992159,0.00002862392,0.0001971669,0.000310464,0.00004505512,0.0002028047],"domain_scores_gemma":[0.9995232,0.00003891451,0.000100425,0.0002033242,0.00008288059,0.00005120549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006474379,0.000320024,0.001570785,0.00002899225,0.00003831924,4.457558e-7,0.00005763864,3.522518e-8,0.992142,0.002343601,0.0002898193,0.00314359],"study_design_scores_gemma":[0.0004419776,0.0001135648,0.00168179,0.00001950543,0.00002198961,0.000008659706,0.00002053544,0.000003954362,0.9942048,0.0002857145,0.003037538,0.0001600064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962947,0.0009377588,0.0001152497,0.0001140752,0.0001787682,0.00008507699,0.00004626165,0.00001070677,0.00221736],"genre_scores_gemma":[0.9978876,0.0003227464,0.001253988,0.0002479684,0.0001342685,1.694881e-7,0.00008016285,0.0000136404,0.00005944935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002983584,"threshold_uncertainty_score":0.519246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007853113242135903,"score_gpt":0.2491130694116775,"score_spread":0.2412599561695415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}