{"id":"W1971668211","doi":"10.1038/nchembio.559","title":"Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy","year":2011,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":521,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Antibiotics; Antimicrobial; Minocycline; Microbiology; Drug; In vivo; Biology; Anti-Infective Agents; Pharmacology; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002824811,0.0005084777,0.0008267573,0.0004860125,0.0001668693,0.0005493773,0.0002729219,0.0003526799,0.002624281],"category_scores_gemma":[0.0005471958,0.0003728002,0.0003716709,0.0003439375,0.0002802877,0.0005835209,0.0004578633,0.0006730905,0.0005292189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000219455,"about_ca_system_score_gemma":0.0002403452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000141243,"about_ca_topic_score_gemma":0.0004412481,"domain_scores_codex":[0.9995576,0.0001053518,0.0000448662,0.00005945269,0.0001476389,0.00008505661],"domain_scores_gemma":[0.9995634,0.0001462476,0.00009564514,0.00004590395,0.00004099642,0.0001077168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008002831,0.0001068039,0.0002637504,0.00007728068,0.00002580868,0.00003273699,0.00001085993,0.000175417,0.9914392,0.00008694943,0.0001033801,0.00687763],"study_design_scores_gemma":[0.00008628298,0.002495007,0.003292292,0.00001220498,0.0001010484,0.0002374635,0.00002067399,0.000588655,0.9900727,0.00008840571,0.002997237,0.000007987885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858849,0.006609714,0.002600074,0.0002755222,0.0001518583,0.0000817922,0.0001795023,0.0001729119,0.004043671],"genre_scores_gemma":[0.9940267,0.001847701,0.002546533,0.00007236664,0.00008042889,0.00002919655,0.0001133065,0.00003806989,0.001245713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002624281,"threshold_uncertainty_score":0.008779049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007853113242135903,"score_gpt":0.2491130694116775,"score_spread":0.2412599561695415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}