{"id":"W1971680848","doi":"10.1182/blood-2008-04-152934","title":"Heme oxygenase-1 expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating factor: a role for increased bilirubin and ferritin","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Versus Arthritis; McGill University","keywords":"HMOX1; Heme oxygenase; Decay-accelerating factor; Hemin; Biliverdin; Heme; Chemistry; Molecular biology; Ferritin; Cytoprotection; Endothelial stem cell; Complement system; Cell biology; Biology; Biochemistry; Oxidative stress; Immunology; Antibody; In vitro; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001337034,0.0001889716,0.0002400924,0.00004231976,0.0001505686,0.00001391777,0.000127675,0.0001266506,0.00001547222],"category_scores_gemma":[0.0001614199,0.0001823619,0.00009182641,0.0000911044,0.00006428027,0.00001258426,0.00007753265,0.00006066604,0.000001090757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009255118,"about_ca_system_score_gemma":0.00007864468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008477526,"about_ca_topic_score_gemma":0.0001284161,"domain_scores_codex":[0.9987128,0.00007853568,0.0003472447,0.0004197172,0.000175174,0.000266576],"domain_scores_gemma":[0.9993538,0.0000310475,0.0001281682,0.0002741079,0.0001052468,0.0001076055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001916342,0.0001650593,0.00149987,0.00004492299,0.00006313238,0.000001423327,0.0002227221,0.000001040644,0.9973247,0.00001356671,0.00036168,0.0001102312],"study_design_scores_gemma":[0.001755513,0.0003239342,0.00175526,0.00004441231,0.00002276322,0.00000393112,0.0002112823,0.000005194563,0.9850029,0.00002364484,0.01064211,0.0002090363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974247,0.000978006,0.0004839196,0.00003239601,0.000048951,0.0005010141,0.0003645368,0.00001956416,0.0001469478],"genre_scores_gemma":[0.9929888,0.0002264446,0.006038949,0.0001191487,0.0002058194,0.000145699,0.0001995271,0.00002802508,0.00004761605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0123218,"threshold_uncertainty_score":0.7436503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02114328769802483,"score_gpt":0.2569876083803682,"score_spread":0.2358443206823434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}