{"id":"W1971692317","doi":"10.1074/jbc.m710534200","title":"PTP1B Regulates Cortactin Tyrosine Phosphorylation by Targeting Tyr446","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Cortactin; Phosphorylation; Tyrosine; Tyrosine phosphorylation; Cell biology; Chemistry; Proto-oncogene tyrosine-protein kinase Src; Biochemistry; Biology; Cell; Cytoskeleton","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008470945,0.0002446383,0.0001099052,0.0001226499,0.0001736456,0.0002203255,0.00008922503,0.0001742345,0.00105731],"category_scores_gemma":[0.00007953888,0.00009478871,0.0001662154,0.00006889204,0.0001594214,0.0001284042,0.0001851248,0.0003705741,0.0002986251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001886607,"about_ca_system_score_gemma":0.0001117597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006435807,"about_ca_topic_score_gemma":0.000720475,"domain_scores_codex":[0.9999261,0.00001001948,0.000005186006,0.00001483677,0.00002089704,0.00002289323],"domain_scores_gemma":[0.9999372,0.000005589026,0.00002546836,0.000003525432,0.000009363588,0.00001882704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003659772,0.0000090293,0.0003846334,0.00001730948,0.000002286097,0.00005587703,0.00001206309,0.00004797952,0.9983233,0.00005842892,0.00004586209,0.001006532],"study_design_scores_gemma":[0.00002258614,0.0001837068,0.04493245,0.00001027316,0.0000176702,0.0009568235,0.00007423487,0.002432012,0.9460205,0.0001769459,0.00516285,0.000009991885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927936,0.002941045,0.00241278,0.0001905043,0.00003384684,0.00001232472,0.0001325646,0.00004835144,0.00143499],"genre_scores_gemma":[0.9962454,0.001324106,0.001040874,0.00005173453,0.00001242083,0.00001091091,0.0001558157,0.000008980463,0.001149706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00105731,"threshold_uncertainty_score":0.003536999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01405301891152779,"score_gpt":0.2342297814249637,"score_spread":0.2201767625134359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}