{"id":"W1971732539","doi":"10.1086/425079","title":"Toll‐Like Receptor (TLR)–3, but Not TLR4, Agonist Protects against Genital Herpes Infection in the Absence of Inflammation Seen with CpG DNA","year":2004,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Health Sciences Centre; McMaster University Medical Centre","funders":"","keywords":"TLR9; TLR3; TLR4; CpG Oligodeoxynucleotide; TLR7; Toll-like receptor; Immunology; TLR2; Inflammation; Biology; Innate immune system; CpG site; Virology; Herpes simplex virus; Virus; Immune system; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000212096,0.0004278162,0.0002979758,0.0002033025,0.000134518,0.0002492703,0.0001542708,0.00028493,0.001653504],"category_scores_gemma":[0.0001943569,0.0001760989,0.0002206186,0.00009567641,0.0002490463,0.00017239,0.0001874089,0.0006698307,0.0004057498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001310342,"about_ca_system_score_gemma":0.0002112814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001529908,"about_ca_topic_score_gemma":0.0002616165,"domain_scores_codex":[0.9998413,0.00004540173,0.00001007454,0.00001700861,0.00002520197,0.00006089669],"domain_scores_gemma":[0.999864,0.00002665186,0.00003284666,0.00002479817,0.00001090824,0.00004073076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003501598,0.00006117063,0.0001262838,0.0000514424,0.00000520645,0.0000282461,0.00000963277,0.000037467,0.9973913,0.00003804399,0.00004586597,0.001855042],"study_design_scores_gemma":[0.00006452483,0.002393624,0.003337977,0.00001869646,0.00001977136,0.0003338649,0.00003377074,0.000382717,0.9913288,0.00009564039,0.001985135,0.000005458201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959065,0.001472647,0.001172586,0.0001243946,0.00005257104,0.00002026703,0.000107594,0.00006277449,0.001080743],"genre_scores_gemma":[0.9945293,0.001081218,0.001679334,0.0001001718,0.00003151467,0.00002801509,0.0002801756,0.00001600605,0.002254197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001653504,"threshold_uncertainty_score":0.00553149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00596479270424296,"score_gpt":0.2108743407162464,"score_spread":0.2049095480120034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}