{"id":"W1971732539","doi":"10.1086/425079","title":"Toll‐Like Receptor (TLR)–3, but Not TLR4, Agonist Protects against Genital Herpes Infection in the Absence of Inflammation Seen with CpG DNA","year":2004,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Health Sciences Centre; McMaster University Medical Centre","funders":"","keywords":"TLR9; TLR3; TLR4; CpG Oligodeoxynucleotide; TLR7; Toll-like receptor; Immunology; TLR2; Inflammation; Biology; Innate immune system; CpG site; Virology; Herpes simplex virus; Virus; Immune system; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006964626,0.0001769497,0.0002625174,0.0002133603,0.0002797578,0.00003461232,0.0002198651,0.0001162835,0.00003366223],"category_scores_gemma":[0.0002465161,0.00009829661,0.0001245933,0.0002904653,0.0002596501,0.0004076668,0.00002391041,0.0003164104,0.00004128397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001243931,"about_ca_system_score_gemma":0.0002798131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002836889,"about_ca_topic_score_gemma":0.0001936613,"domain_scores_codex":[0.9983889,0.0006171833,0.0005566971,0.00009476025,0.0001335898,0.0002088622],"domain_scores_gemma":[0.9985574,0.0002425355,0.0007130984,0.0002237081,0.0002435428,0.00001964122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004823116,0.0006446648,0.01143045,0.0001306672,0.0004488598,0.00002702772,0.004694822,0.005523081,0.9585699,0.0003459684,0.0002191746,0.01314229],"study_design_scores_gemma":[0.00563007,0.002228416,0.2460347,0.0004933662,0.0001977589,0.0009873486,0.001274174,0.000007679696,0.74011,0.0006562312,0.002055655,0.0003245688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977099,0.000570485,0.0003590467,0.0003760754,0.0002710535,0.0004656546,0.000009190347,0.00002510302,0.0002134324],"genre_scores_gemma":[0.9992551,0.0004377042,0.00000797492,0.0000935049,0.0000993398,0.00002635171,0.00001618252,0.00001331749,0.00005052763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2346042,"threshold_uncertainty_score":0.4008419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00596479270424296,"score_gpt":0.2108743407162464,"score_spread":0.2049095480120034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}