{"id":"W1971757865","doi":"10.2337/db14-1223","title":"Reduced Expression of the MDA5 Gene <i>IFIH1</i> Prevents Autoimmune Diabetes","year":2015,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Diabetes Association; Juvenile Diabetes Research Foundation International","keywords":"Autoimmunity; Biology; MDA5; Gene; Interferon; Locus (genetics); Virology; Immunology; RNA; Immune system; RNA interference; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002636857,0.0001753222,0.0002117104,0.00001818435,0.00007025232,0.0000200962,0.0004067156,0.0001519913,0.00001050651],"category_scores_gemma":[0.0002320532,0.000127975,0.0001666108,0.0001401354,0.0001031384,0.000007097415,0.0002691237,0.00009257797,0.000007586867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000126213,"about_ca_system_score_gemma":0.00006992303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004697371,"about_ca_topic_score_gemma":7.71951e-7,"domain_scores_codex":[0.9987691,0.0001159507,0.000253426,0.0002716217,0.0002201364,0.000369762],"domain_scores_gemma":[0.9991018,0.00001666464,0.0001888244,0.000503874,0.0001013987,0.00008745872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005348139,0.0001083084,0.05702591,0.00001439201,0.00004932438,5.879574e-8,0.00004810085,0.00004674203,0.934895,0.00000512868,0.006695272,0.001106445],"study_design_scores_gemma":[0.0006054777,0.0001184078,0.008246997,0.0000563744,0.00002651349,5.091049e-8,0.00006338531,0.00003377687,0.9831836,0.0002427394,0.00725229,0.0001703452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954927,0.002686935,0.000002540964,0.0001731287,0.0003553565,0.0001919649,0.0000416275,0.0000177823,0.001037965],"genre_scores_gemma":[0.9986914,0.00003523849,0.000137179,0.0002982198,0.00008321567,0.0000349383,0.0001100648,0.00002918145,0.0005805162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04877891,"threshold_uncertainty_score":0.5218671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008052728939860372,"score_gpt":0.2178487167525957,"score_spread":0.2097959878127353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}