{"id":"W1971758210","doi":"10.1016/j.bpj.2011.11.2984","title":"Allosteric Coupling Between the CFTR Chloride Channel's NBD1 Heterodimer Interface and Intracellular Domains","year":2012,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Allosteric regulation; Chloride channel; Helix (gastropod); Cyclic nucleotide-binding domain; Chemistry; Biophysics; Transmembrane domain; Mutation; Binding site; Dimer; Cystic fibrosis transmembrane conductance regulator; Salt bridge; Crystallography; Nucleotide; Biochemistry; Biology; Membrane; Mutant; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003404121,0.0002321426,0.0003584194,0.0001237714,0.0004534337,0.0005752194,0.0006496289,0.0004409731,0.004038471],"category_scores_gemma":[0.0008858007,0.0002586981,0.0001929823,0.0001018502,0.0005786226,0.0006774788,0.0008605078,0.0009055574,0.0007573341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004999039,"about_ca_system_score_gemma":0.000334831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005718856,"about_ca_topic_score_gemma":0.0009906467,"domain_scores_codex":[0.9997988,0.00004370409,0.00001546086,0.00004013509,0.00005088431,0.00005091757],"domain_scores_gemma":[0.999808,0.00008625969,0.00002345152,0.00002539722,0.00002154053,0.00003530731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004910519,0.00009574634,0.0008667756,0.0001586627,0.00001488503,0.0002894009,0.000193056,0.000745865,0.9857215,0.004870243,0.0009463055,0.005606498],"study_design_scores_gemma":[0.0003171368,0.0002128933,0.00841098,0.00007634766,0.00004210752,0.00111394,0.0004817258,0.03214081,0.9441634,0.003275926,0.009709418,0.00005526749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823814,0.0008283117,0.007450193,0.001337792,0.0002115935,0.00003334399,0.000101673,0.0001961184,0.007459467],"genre_scores_gemma":[0.9971049,0.0002684919,0.001254253,0.0002613188,0.00001825255,0.00001818387,0.00006581334,0.00002359884,0.0009850771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004038471,"threshold_uncertainty_score":0.01351005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02567293571432132,"score_gpt":0.3110640213050098,"score_spread":0.2853910855906885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}