{"id":"W1971761143","doi":"10.1007/s00232-009-9167-3","title":"Novel Residues Lining the CFTR Chloride Channel Pore Identified by Functional Modification of Introduced Cysteines","year":2009,"lang":"en","type":"article","venue":"The Journal of Membrane Biology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Chemistry; Permeation; Cystic fibrosis transmembrane conductance regulator; Cysteine; Chloride channel; Side chain; Amino acid; Transmembrane protein; Ion channel; Mutagenesis; Biophysics; Membrane; Gating; Transmembrane domain; Biochemistry; Organic chemistry; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002874123,0.0004003673,0.0004388659,0.0001766412,0.0003141054,0.0003409784,0.0005501594,0.0009580937,0.001732689],"category_scores_gemma":[0.0005968792,0.0001892561,0.000474535,0.0001529927,0.0005601074,0.0003466374,0.0004285864,0.0008809206,0.000586629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003251577,"about_ca_system_score_gemma":0.0002551122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004580303,"about_ca_topic_score_gemma":0.0005251119,"domain_scores_codex":[0.9998235,0.00003640969,0.00002284186,0.00003657158,0.00004755435,0.00003303882],"domain_scores_gemma":[0.9995177,0.00009678033,0.0001713593,0.00005599961,0.00005945139,0.00009873782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005276809,0.00004703976,0.0003981135,0.00005838698,0.00002468743,0.00134943,0.00005526071,0.0002828842,0.9945431,0.0007070733,0.0001003813,0.00190591],"study_design_scores_gemma":[0.0001405308,0.0005701715,0.006029529,0.00002276271,0.00009891087,0.004264748,0.00008504892,0.003138154,0.9817167,0.0004919915,0.003392725,0.00004883348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898456,0.000327596,0.008186031,0.0001982972,0.0001591795,0.00005047176,0.0002036774,0.00009904847,0.0009301216],"genre_scores_gemma":[0.9943478,0.0001427939,0.00447761,0.00009378163,0.00002582527,0.00002108522,0.0001672346,0.00002522366,0.0006987218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001732689,"threshold_uncertainty_score":0.005796373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04106540320963782,"score_gpt":0.3246157042380349,"score_spread":0.2835503010283971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}