{"id":"W1971771552","doi":"10.1371/journal.pone.0006651","title":"RNA Silencing of Mcl-1 Enhances ABT-737-Mediated Apoptosis in Melanoma: Role for a Caspase-8-Dependent Pathway","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lions Gate Hospital; Queen's University; Vancouver Coastal Health; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Killam Trusts; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; University of Alberta","keywords":"Melanoma; Apoptosis; Cancer research; Programmed cell death; Caspase 8; Caspase; Caspase 3; Gene knockdown; Biology; Caspase 2; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001329996,0.0003220132,0.0001776767,0.0002439852,0.0001937971,0.0002591298,0.000159199,0.0002048469,0.001561063],"category_scores_gemma":[0.00007178534,0.00007139001,0.0002212199,0.000126042,0.0002342568,0.0001624088,0.0001167751,0.0006047708,0.0003850633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004390508,"about_ca_system_score_gemma":0.0002909645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008083273,"about_ca_topic_score_gemma":0.001574454,"domain_scores_codex":[0.9998825,0.00001553168,0.00001142365,0.00001905504,0.00004177442,0.00002972805],"domain_scores_gemma":[0.9999154,0.00001386413,0.00002407152,0.000006927792,0.00001503207,0.00002474038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006867042,0.00003832725,0.00008558063,0.00003067098,0.000003915232,0.00002009768,0.000007186773,0.00004173015,0.998926,0.00004230141,0.00003484331,0.0007005692],"study_design_scores_gemma":[0.0000149991,0.0003678257,0.00142107,0.000003745342,0.00001968051,0.00007339052,0.00001660681,0.0005913051,0.9964297,0.00001482759,0.001044436,0.000002405868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934378,0.001546751,0.002430465,0.0001393523,0.00004512386,0.00006526951,0.000358762,0.000178079,0.001798374],"genre_scores_gemma":[0.9960722,0.0005819966,0.001550483,0.00004609818,0.000008487655,0.00004791966,0.0002924214,0.00001686784,0.00138373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001561063,"threshold_uncertainty_score":0.005222321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01462208933034157,"score_gpt":0.2107860205651095,"score_spread":0.1961639312347679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}