{"id":"W1971784984","doi":"10.1016/j.bmcl.2013.04.043","title":"Identification of potent and orally bioavailable nucleotide competing reverse transcriptase inhibitors: In vitro and in vivo optimization of a series of benzofurano[3,2-d]pyrimidin-2-one derived inhibitors","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Reverse transcriptase; Potency; Bioavailability; In vivo; Pharmacology; Pharmacokinetics; Enzyme inhibitor; Enzyme; CYP3A4; Efflux; Reverse-transcriptase inhibitor; Biochemistry; In vitro; Cytochrome P450; Biology; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002402458,0.0005666812,0.0006045647,0.0003538511,0.0001757757,0.0004050354,0.0003860816,0.0002796974,0.001368236],"category_scores_gemma":[0.0001917024,0.0002666901,0.000252453,0.0002742635,0.0001934207,0.0002632413,0.0001784373,0.0007693919,0.0003532208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003500992,"about_ca_system_score_gemma":0.0003547375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007390723,"about_ca_topic_score_gemma":0.003409874,"domain_scores_codex":[0.9998887,0.0000220148,0.000008405011,0.0000182944,0.00002933978,0.00003323263],"domain_scores_gemma":[0.9999292,0.00001311949,0.00001714979,0.000005800303,0.00001285189,0.0000218247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008557092,0.0006551369,0.0004204704,0.0002101599,0.00004390768,0.0002351705,0.00005841672,0.00250827,0.9777197,0.0003385273,0.0004280156,0.01652654],"study_design_scores_gemma":[0.0009171191,0.01040873,0.004085529,0.00005247198,0.0002391415,0.001045329,0.00005398892,0.003773105,0.9671512,0.000130466,0.01209956,0.00004331959],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779515,0.0117766,0.005675269,0.0002762447,0.0000578995,0.000278179,0.0009450387,0.0001185388,0.002920732],"genre_scores_gemma":[0.9754995,0.01244072,0.005910147,0.00016384,0.0000325611,0.0001435866,0.002056892,0.00003555447,0.003717139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001368236,"threshold_uncertainty_score":0.00457716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007814370448937416,"score_gpt":0.1949019201887962,"score_spread":0.1870875497398588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}