{"id":"W1971798635","doi":"10.1006/mgme.2001.3189","title":"In Vivo Variability of TMA Oxidation Is Partially Mediated by Polymorphisms of the FMO3 Gene","year":2001,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"Cégep de Chicoutimi; Centre Hospitalier de l’Université de Montréal; McGill University; Montreal Children's Hospital","funders":"","keywords":"Trimethylamine; Monooxygenase; In vivo; Genotype; Substrate (aquarium); Gene; Enzyme; Flavin group; Chemistry; Biology; Genetics; In vitro; Flavin-containing monooxygenase; Biochemistry; Cytochrome P450","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003828405,0.0002001715,0.0003043608,0.00005519237,0.00003332285,0.00001005766,0.0002846849,0.0001826328,0.00007231424],"category_scores_gemma":[0.0001100771,0.0001676135,0.0001172932,0.0002615864,0.0001957939,0.000003988134,0.0001655332,0.00006952725,7.607437e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001806435,"about_ca_system_score_gemma":0.00008335162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001107569,"about_ca_topic_score_gemma":0.00002997041,"domain_scores_codex":[0.9984303,0.0001947348,0.0004715624,0.0003853235,0.0002639453,0.0002541751],"domain_scores_gemma":[0.9989766,0.00001247868,0.000197339,0.0006134483,0.0001140172,0.00008610046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003580258,0.0001114935,0.007653778,0.0000118813,0.00004540349,8.123483e-7,0.00009375317,0.00006416719,0.9900522,0.000218986,0.000522484,0.001189206],"study_design_scores_gemma":[0.0008612621,0.00003590885,0.03068389,0.00000538318,0.00006750881,0.000004400674,0.00001738855,0.00009137844,0.9102669,0.0007111385,0.05709012,0.0001646628],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829839,0.01277586,0.00293159,0.0003427638,0.0001939075,0.0002896675,0.0001007211,0.000002609294,0.0003790157],"genre_scores_gemma":[0.9936585,0.004566669,0.000805183,0.000670875,0.00004128974,0.00001632291,0.00003443221,0.00002317393,0.0001835317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07978527,"threshold_uncertainty_score":0.6835078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004198898728176282,"score_gpt":0.2125738455558094,"score_spread":0.2083749468276331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}