{"id":"W1971837501","doi":"10.1089/10430340252792503","title":"Adenovirus Vector-Induced Inflammation: Capsid-Dependent Induction of the C-C Chemokine RANTES Requires NF- <i>κ</i> B","year":2002,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research","keywords":"Chemokine; Transduction (biophysics); Molecular biology; Adenoviridae; Biology; Inflammation; Cell biology; Signal transduction; HeLa; Genetic enhancement; Cell; Immunology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002758266,0.0005142228,0.0002854023,0.000253285,0.0001771597,0.0004118412,0.0002236587,0.0003137693,0.002068885],"category_scores_gemma":[0.0002048076,0.0001863155,0.0002892381,0.000202739,0.0003018809,0.0003186438,0.0002144554,0.0007702869,0.0005902469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005362488,"about_ca_system_score_gemma":0.0003546329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007842578,"about_ca_topic_score_gemma":0.001013368,"domain_scores_codex":[0.9997049,0.00005520746,0.00004008962,0.00005360386,0.00007573145,0.00007058341],"domain_scores_gemma":[0.9998381,0.00004662244,0.00003700561,0.00002615072,0.00002022892,0.00003183428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001373808,0.00005010004,0.00007931178,0.00006085994,0.000003801309,0.00003006632,0.00001715967,0.00002968321,0.9987159,0.0001647161,0.0000464827,0.0006645674],"study_design_scores_gemma":[0.00003997204,0.0004427471,0.001939239,0.00001175264,0.00001263852,0.0002399613,0.00002056815,0.0006315936,0.9928073,0.00005514411,0.00379371,0.000005339572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783103,0.003195986,0.01232494,0.0001745104,0.0001701286,0.0002726294,0.00137709,0.0003344977,0.003839897],"genre_scores_gemma":[0.977899,0.001694081,0.009659761,0.0000854813,0.00002503524,0.0002404407,0.002534359,0.00005778529,0.007803962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002068885,"threshold_uncertainty_score":0.006921113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04820848814826027,"score_gpt":0.2910092560336451,"score_spread":0.2428007678853848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}