{"id":"W1971858687","doi":"10.1038/mtna.2012.35","title":"Antisense 2′-Deoxy, 2′-Fluoroarabino Nucleic Acid (2′F-ANA) Oligonucleotides: In Vitro Gymnotic Silencers of Gene Expression Whose Potency Is Enhanced by Fatty Acids","year":2012,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Gene silencing; LNCaP; Oligonucleotide; Locked nucleic acid; Nucleic acid; Molecular biology; Biology; Phosphodiester bond; Biochemistry; Chemistry; RNA; DNA; Gene; Cancer cell; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002249253,0.0004672013,0.0002448721,0.0001650321,0.0001576092,0.0002322415,0.0002367666,0.0003128606,0.001165755],"category_scores_gemma":[0.000144936,0.0001981562,0.0002289526,0.000114521,0.0002007667,0.0001577925,0.0001440313,0.0004599695,0.0006771181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002782938,"about_ca_system_score_gemma":0.0001614171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006484916,"about_ca_topic_score_gemma":0.001137676,"domain_scores_codex":[0.9997637,0.00004886894,0.00002017852,0.00007798449,0.00005760431,0.00003172756],"domain_scores_gemma":[0.9999121,0.00002036134,0.00002781595,0.00001081929,0.000013601,0.00001531144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002101774,0.000005979577,0.00001587719,0.00002012238,0.000001384266,0.000008494188,0.000008242293,0.00003826778,0.9991869,0.00004771103,0.00001770505,0.0006282761],"study_design_scores_gemma":[0.000006161681,0.0001431314,0.0001746905,0.00000231205,0.000006271888,0.00005151305,0.000004529896,0.0002037083,0.9964539,0.00001049229,0.002940445,0.00000281003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9359245,0.003963246,0.04952465,0.0001886131,0.0002424785,0.0003454906,0.000887645,0.0007315948,0.008191754],"genre_scores_gemma":[0.9551739,0.002871159,0.02806335,0.0001447479,0.00004329978,0.0003129666,0.001330954,0.0001065754,0.0119531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001165755,"threshold_uncertainty_score":0.003899813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008719407089710725,"score_gpt":0.2381416329266385,"score_spread":0.2294222258369277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}