{"id":"W1971858687","doi":"10.1038/mtna.2012.35","title":"Antisense 2′-Deoxy, 2′-Fluoroarabino Nucleic Acid (2′F-ANA) Oligonucleotides: In Vitro Gymnotic Silencers of Gene Expression Whose Potency Is Enhanced by Fatty Acids","year":2012,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Gene silencing; LNCaP; Oligonucleotide; Locked nucleic acid; Nucleic acid; Molecular biology; Biology; Phosphodiester bond; Biochemistry; Chemistry; RNA; DNA; Gene; Cancer cell; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003800869,0.0006412643,0.0006542964,0.000203703,0.0001257106,0.00005035833,0.0007753645,0.0005414826,0.0002224056],"category_scores_gemma":[0.00005249261,0.0006216566,0.00043333,0.0003681782,0.0002874874,0.00006275853,0.0002021704,0.0003184261,0.00008177965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006960044,"about_ca_system_score_gemma":0.00009298635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006981707,"about_ca_topic_score_gemma":0.000002451387,"domain_scores_codex":[0.9965299,0.0002863519,0.0007645463,0.0008927219,0.0005044038,0.001022035],"domain_scores_gemma":[0.9979461,0.00001644826,0.0003246024,0.001224226,0.0001805202,0.000308033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007593474,0.000422725,0.002141385,0.00003191485,0.0001466665,0.0000138238,0.0007464858,0.00002912028,0.9837274,0.000004913952,0.0008638868,0.01111233],"study_design_scores_gemma":[0.001728034,0.0005878951,0.001774054,0.00007876434,0.00003625133,0.00001656055,0.0003253481,0.0000554738,0.9925859,0.00004350259,0.002082215,0.0006860123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847167,0.008337874,0.005228535,0.0001367704,0.0003342689,0.0005116076,0.0001275749,0.00004349746,0.0005631748],"genre_scores_gemma":[0.992382,0.002357274,0.003070801,0.001421525,0.0001439867,0.00005323358,0.0002267647,0.0001305537,0.0002138531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01042632,"threshold_uncertainty_score":0.9996235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008719407089710725,"score_gpt":0.2381416329266385,"score_spread":0.2294222258369277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}