{"id":"W1971883527","doi":"10.1126/scitranslmed.3006299","title":"Intranasal Antibody Gene Transfer in Mice and Ferrets Elicits Broad Protection Against Pandemic Influenza","year":2013,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Nasal administration; Gene transfer; Virology; Pandemic; Antibody; Pandemic influenza; Influenza A virus; Antibody response; Biology; Gene; Immunology; Medicine; Coronavirus disease 2019 (COVID-19); Virus; Genetics; Infectious disease (medical specialty); Disease; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004533505,0.0008660351,0.0004921767,0.0007526062,0.0002771954,0.000487878,0.0004335972,0.0009558175,0.001036238],"category_scores_gemma":[0.0002381456,0.0002796871,0.0005463944,0.0001222058,0.0008031957,0.0006317983,0.0002650185,0.001633804,0.0004508385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005130476,"about_ca_system_score_gemma":0.0003154971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008040607,"about_ca_topic_score_gemma":0.001137701,"domain_scores_codex":[0.9997274,0.00003743896,0.00001775241,0.00007472324,0.00004425572,0.0000984441],"domain_scores_gemma":[0.9998243,0.00003653003,0.00004753616,0.0000251014,0.0000147685,0.00005166038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000346872,0.0003809144,0.0001289574,0.00003776233,0.00001043283,0.00004600584,0.00004194768,0.0001346721,0.9961299,0.0001918029,0.0001197044,0.002431074],"study_design_scores_gemma":[0.0002440265,0.00893499,0.003863231,0.00003680667,0.00005231816,0.0003960171,0.00006662577,0.001629753,0.981972,0.0002840427,0.002506582,0.0000135083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923706,0.001002846,0.003497217,0.0004581619,0.0001083856,0.0001133694,0.0002003798,0.0002813571,0.001967696],"genre_scores_gemma":[0.9924931,0.000957471,0.002511055,0.000235877,0.00005575962,0.0001102144,0.0002958205,0.00004501633,0.003295707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001036238,"threshold_uncertainty_score":0.003722429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03221681122553161,"score_gpt":0.3419068226558003,"score_spread":0.3096900114302687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}