{"id":"W1971887691","doi":"10.1159/000185461","title":"RETProto-Oncogene Mutations in Multiple Endocrine Neoplasia Type 2 and Medullary Thyroid Carcinoma","year":2008,"lang":"en","type":"review","venue":"Hormone Research","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Multiple endocrine neoplasia type 2; Missense mutation; RET proto-oncogene; Multiple endocrine neoplasia; Germline mutation; Proto-Oncogene Proteins c-ret; Medicine; Thyroid carcinoma; Penetrance; Medullary thyroid cancer; Pheochromocytoma; Cancer research; Medullary carcinoma; Germline; Internal medicine; Thyroid; Mutation; Genetics; Biology; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001332862,0.0002387312,0.0001682879,0.0006477105,0.0003142986,0.0002416176,0.000177915,0.0005803865,0.001211846],"category_scores_gemma":[0.0006587094,0.0001126169,0.000253973,0.0004482502,0.0002248156,0.0001710694,0.0002619832,0.0001424704,0.0002274021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004646353,"about_ca_system_score_gemma":0.0002909456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004208448,"about_ca_topic_score_gemma":0.006106831,"domain_scores_codex":[0.9998604,0.00001283544,0.00001418094,0.00003040521,0.00005166451,0.00003058482],"domain_scores_gemma":[0.9998611,0.0000295052,0.00004091268,0.000008533936,0.00002053412,0.00003946974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005833174,0.00008287406,0.2777959,0.0004868796,0.0002137553,0.5111336,0.00151284,0.00100255,0.1585068,0.002739574,0.002726209,0.04321568],"study_design_scores_gemma":[0.00008037989,0.0002361609,0.332878,0.0001078858,0.0001858225,0.6285406,0.0004985542,0.001007878,0.01176676,0.0009213487,0.02372345,0.00005320565],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9800662,0.009590204,0.0004583467,0.0003168492,0.00005016234,0.00002770045,0.0002636148,0.00005470017,0.009172304],"genre_scores_gemma":[0.9973419,0.0009953645,0.0002153439,0.00008535142,0.00003074601,0.000006464842,0.0001060914,0.000005495511,0.001213214],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.004208448,"threshold_uncertainty_score":0.008367896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1664329825053621,"score_gpt":0.4253074514568034,"score_spread":0.2588744689514413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}