{"id":"W1971922559","doi":"10.1100/tsw.2001.178","title":"Granzyme B Induces Bid-Mediated Cytochrome C Release and Mitochondrial Permeability Transition","year":2001,"lang":"en","type":"article","venue":"The Scientific World JOURNAL","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Cancer Institute; Medical Research Council; Medical Research Council Canada","keywords":"Mitochondrial permeability transition pore; Chemistry; Cytochrome c; Granzyme B; Cytochrome; Cell biology; Apoptosome; Mitochondrial apoptosis-induced channel; Mitochondrion; Apoptosis; Biochemistry; Biology; Caspase; Programmed cell death; Enzyme; Cytotoxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007634718,0.0001378447,0.0001325151,0.0001336309,0.0007252194,0.0002207222,0.0002094468,0.00008965388,0.0004078985],"category_scores_gemma":[0.0001664122,0.00009468435,0.0001069651,0.0003506731,0.000473009,0.00001377162,0.00004355665,0.0002851204,0.00004477205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001506324,"about_ca_system_score_gemma":0.00009500767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008020619,"about_ca_topic_score_gemma":0.00015601,"domain_scores_codex":[0.9985693,0.0003009184,0.0002712151,0.0003532096,0.0002282416,0.0002771315],"domain_scores_gemma":[0.9992489,0.00003268922,0.0001055381,0.0003187918,0.0001327744,0.0001612977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003240241,0.00005120319,0.0001245316,0.000003332269,0.0000182452,0.00001580421,0.0002579676,0.00003823377,0.9837075,0.00002958777,0.01457258,0.0008569869],"study_design_scores_gemma":[0.005956104,0.0008704127,0.01164676,0.00007026616,0.0001860125,0.005668387,0.0008847145,0.0004020156,0.1357411,0.003055833,0.8345753,0.0009431552],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921039,0.0004163775,0.0008955388,0.002893705,0.002862505,0.0001874459,0.00001792949,0.00001360225,0.0006089664],"genre_scores_gemma":[0.9917053,0.0001244303,0.000222744,0.0004287813,0.001507566,0.000008166083,0.00006735128,0.00001237385,0.005923301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8479664,"threshold_uncertainty_score":0.5577875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01488454064835248,"score_gpt":0.2433739433823007,"score_spread":0.2284894027339482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}