{"id":"W1971924559","doi":"10.1007/s10989-007-9093-0","title":"Alcohols as Replacements of the Central Amide in β-Turns, Synthesis of Pro-Aib Hydroxyethylene Isostere and Analysis in Model β-Turn Peptides","year":2007,"lang":"en","type":"article","venue":"International Journal of Peptide Research and Therapeutics","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Amide; Isostere; Hydrogen bond; Intramolecular force; Ketone; Hydrogen bromide; Dipeptide; Alcohol; Stereochemistry; Medicinal chemistry; Bromide; Ring (chemistry); Amine gas treating; Peptide; Organic chemistry; Molecule; Bromine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001494279,0.00009758888,0.0002616215,0.0003644317,0.0000195446,0.00002317375,0.0003449638,0.0000905206,0.000008261035],"category_scores_gemma":[0.0002986919,0.00006861942,0.000161402,0.0003034399,0.0001929795,0.00001347038,0.0001544551,0.0002095929,9.862288e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004603415,"about_ca_system_score_gemma":0.00007988127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001272195,"about_ca_topic_score_gemma":0.0006079561,"domain_scores_codex":[0.9983253,0.0001107063,0.0005878156,0.0001619839,0.0005892725,0.0002249529],"domain_scores_gemma":[0.9989341,0.00018259,0.0002811642,0.000153708,0.00037532,0.00007310756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000646827,0.0002440995,0.3368843,0.00002425295,0.001004665,0.000009872389,0.000254794,0.0004198443,0.6538042,0.00008603606,0.000008104562,0.006612976],"study_design_scores_gemma":[0.0008194949,0.0001949303,0.1178833,0.0002173287,0.0001381416,0.00002299582,0.0007799467,0.002259528,0.8751557,0.002176814,0.0002332822,0.0001185696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978619,0.001150949,0.0001535029,0.0004059149,0.00001563536,0.00007007829,0.00001871355,4.485895e-7,0.0003229226],"genre_scores_gemma":[0.9963484,0.00314897,0.0002839137,0.0000450422,0.00004682538,0.000001576382,0.000003516663,0.000007520729,0.000114229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2213514,"threshold_uncertainty_score":0.2798218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03568442958669056,"score_gpt":0.3663554812352436,"score_spread":0.330671051648553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}