{"id":"W1971947032","doi":"10.1021/jm900921c","title":"Potent and Selective Steroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 7, an Enzyme That Catalyzes the Reduction of the Key Hormones Estrone and Dihydrotestosterone","year":2009,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Dihydrotestosterone; Hydroxysteroid dehydrogenase; Estrone; Steroid; Stereochemistry; Enzyme; Dehydrogenase; Androstane; Benzamide; Hormone; Biochemistry; Androgen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002381928,0.0008688035,0.0005283205,0.0002729755,0.0001520293,0.0002597249,0.0004323357,0.0003230263,0.001483691],"category_scores_gemma":[0.0002066194,0.0002108354,0.000367038,0.0002689417,0.0002650849,0.0002881132,0.0002200501,0.0008324931,0.001096421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003641312,"about_ca_system_score_gemma":0.0003769691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007307641,"about_ca_topic_score_gemma":0.001823313,"domain_scores_codex":[0.9997311,0.00004331356,0.00002310918,0.00005949779,0.00007880801,0.00006420074],"domain_scores_gemma":[0.9998964,0.00002101877,0.00002903779,0.00001294526,0.00002150407,0.00001907504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002219811,0.0001295457,0.0002980015,0.0002067549,0.000032481,0.00009602863,0.00002823638,0.0003518321,0.9827591,0.0003200908,0.000233321,0.01532278],"study_design_scores_gemma":[0.00006003076,0.001513495,0.001480801,0.00001142188,0.0000582801,0.0004602988,0.00001673624,0.000377652,0.9823339,0.00005110038,0.01362279,0.0000133104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.863208,0.09431256,0.02359013,0.0003520341,0.00035771,0.0007214167,0.001867049,0.0005009201,0.01509026],"genre_scores_gemma":[0.9368858,0.02849483,0.01787119,0.0002068581,0.0001132107,0.0003634997,0.002422469,0.0000483674,0.01359367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001483691,"threshold_uncertainty_score":0.004963398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005824839498426085,"score_gpt":0.2191959060421439,"score_spread":0.2133710665437178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}