{"id":"W1971948655","doi":"10.1042/bj20121280","title":"Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5","year":2012,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Ottawa; University of Toronto; Ontario Institute for Cancer Research; Structural Genomics Consortium","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"H3K4me3; Small molecule; Histone methyltransferase; Methyltransferase; Biology; Histone H3; Protein–protein interaction; Enhancer; In vitro; Histone; Peptide; EZH2; Chemistry; Cell biology; Biochemistry; Methylation; Transcription factor; Promoter; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001354553,0.0002957416,0.0002733649,0.00009564229,0.000129109,0.0001831441,0.0003510287,0.0002267388,0.001042751],"category_scores_gemma":[0.0001115928,0.0000968474,0.0002017582,0.00006680431,0.0002159577,0.000106127,0.0001598616,0.0005115308,0.0002569444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002467292,"about_ca_system_score_gemma":0.0001533275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003527981,"about_ca_topic_score_gemma":0.0006576242,"domain_scores_codex":[0.9999081,0.00001998363,0.000007281672,0.00001500629,0.00002277992,0.00002684318],"domain_scores_gemma":[0.9999478,0.00001821193,0.0000129154,0.000005273217,0.000003307327,0.00001248383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002011411,0.00009284226,0.00007425497,0.0000477736,0.00001597205,0.00004239406,0.000009813061,0.0001639077,0.9977864,0.000153151,0.00005835341,0.00135404],"study_design_scores_gemma":[0.00009242722,0.0008001893,0.001030769,0.000005474697,0.0000224118,0.0001445975,0.00001124854,0.001747831,0.9934794,0.00003625316,0.002624219,0.000005341189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936428,0.001648973,0.002688487,0.0001353605,0.00003813214,0.00004580048,0.0001245486,0.00005936401,0.001616534],"genre_scores_gemma":[0.9965327,0.0007846267,0.001311454,0.00005859575,0.00001114797,0.00003176524,0.0002017138,0.000006518641,0.001061496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001042751,"threshold_uncertainty_score":0.003488362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01828088447171968,"score_gpt":0.2714335820510332,"score_spread":0.2531526975793136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}