{"id":"W1971953906","doi":"10.1021/bi034772u","title":"Toward the Elucidation of the Catalytic Mechanism of the Mono-ADP-Ribosyltransferase Activity of <i>Pseudomonas aeruginosa</i> Exotoxin A","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"NAD+ kinase; Nicotinamide; Chemistry; Substrate (aquarium); Enzyme; Stereochemistry; Enzyme kinetics; Quenching (fluorescence); Non-competitive inhibition; Catalytic cycle; Nicotinamide adenine dinucleotide; Anthrax toxin; Pseudomonas exotoxin; Biochemistry; Active site; Fluorescence; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002255208,0.0003877398,0.0003073373,0.0001256869,0.0001264881,0.0005396982,0.0004209741,0.0005389503,0.000531962],"category_scores_gemma":[0.0005450215,0.0001554825,0.0002758942,0.0001246119,0.0003259699,0.0005868386,0.000151772,0.0006982842,0.0003382525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008183616,"about_ca_system_score_gemma":0.0003964047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001775255,"about_ca_topic_score_gemma":0.0008284631,"domain_scores_codex":[0.9998467,0.00004203852,0.00001176907,0.00003889886,0.00003605903,0.00002442022],"domain_scores_gemma":[0.9998152,0.00006746788,0.00004671697,0.00001753367,0.00003792938,0.0000152649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001046093,0.00003940202,0.001779404,0.00009456643,0.00000816472,0.00005065968,0.00003664493,0.0005570873,0.9931218,0.0008943927,0.00004140855,0.00327181],"study_design_scores_gemma":[0.000008666749,0.0002121477,0.008693807,0.00001194836,0.00001435923,0.0003774361,0.00003957204,0.01386444,0.974738,0.0005027711,0.001521921,0.00001489875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9579445,0.003394171,0.03658251,0.0002347863,0.00002077754,0.00004297041,0.0002328974,0.0001656086,0.001381769],"genre_scores_gemma":[0.9893818,0.001438463,0.007761817,0.00004624861,0.000006300204,0.0000238295,0.0003295864,0.0000154334,0.0009966438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001775255,"threshold_uncertainty_score":0.005937636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01199327558211686,"score_gpt":0.2062240659388656,"score_spread":0.1942307903567487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}