{"id":"W1971953906","doi":"10.1021/bi034772u","title":"Toward the Elucidation of the Catalytic Mechanism of the Mono-ADP-Ribosyltransferase Activity of <i>Pseudomonas aeruginosa</i> Exotoxin A","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"NAD+ kinase; Nicotinamide; Chemistry; Substrate (aquarium); Enzyme; Stereochemistry; Enzyme kinetics; Quenching (fluorescence); Non-competitive inhibition; Catalytic cycle; Nicotinamide adenine dinucleotide; Anthrax toxin; Pseudomonas exotoxin; Biochemistry; Active site; Fluorescence; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000364094,0.0002007772,0.0002923952,0.00001921901,0.000139236,0.000005123477,0.000683088,0.0002807149,0.000119372],"category_scores_gemma":[0.0001902573,0.0001099946,0.0002919833,0.0002291681,0.0004112698,0.00004011505,0.0001120479,0.000322008,0.000005405574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003362579,"about_ca_system_score_gemma":0.0002093575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001155161,"about_ca_topic_score_gemma":0.000007021771,"domain_scores_codex":[0.9988386,0.0002115751,0.0003714145,0.0002384891,0.0001033952,0.0002365408],"domain_scores_gemma":[0.9984807,0.0001104793,0.0003392976,0.0009648986,0.00009057052,0.00001398869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005719066,0.0001711758,0.00008740793,0.00008500126,0.00009957219,2.059217e-7,0.0003720585,0.000002823341,0.9960254,0.002593077,0.0001436965,0.0003623916],"study_design_scores_gemma":[0.00064524,0.00004567691,0.0005168813,0.00006911509,0.00008768822,0.00002890214,0.000381502,0.000003363884,0.9972504,0.0004604535,0.0003954906,0.0001152752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965762,0.0006505054,0.0007691439,0.0003165966,0.0004341043,0.0004016111,0.0001476193,0.00001223382,0.000692007],"genre_scores_gemma":[0.9990058,0.00004914705,0.00003674015,0.00005866721,0.00001062172,0.00002522372,0.00001047462,0.00001491145,0.0007884093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002429626,"threshold_uncertainty_score":0.448545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01199327558211686,"score_gpt":0.2062240659388656,"score_spread":0.1942307903567487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}