{"id":"W1971972260","doi":"10.1002/pros.20674","title":"Androgen‐mediated cholesterol metabolism in LNCaP and PC‐3 cell lines is regulated through two different isoforms of acyl‐coenzyme A: Cholesterol Acyltransferase (ACAT)","year":2007,"lang":"en","type":"article","venue":"The Prostate","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"National Cancer Institute; Terry Fox Foundation; Michael Smith Health Research BC; VGH and UBC Hospital Foundation","keywords":"LNCaP; Sterol O-acyltransferase; Endocrinology; Internal medicine; Androgen; Androgen receptor; Cholesterol; Reductase; Biology; Prostate cancer; Chemistry; Medicine; Enzyme; Biochemistry; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004164648,0.0003565075,0.0004501299,0.00008265283,0.00008512318,0.00003534091,0.0002862329,0.0001679743,0.00001456262],"category_scores_gemma":[0.00002353523,0.0002423325,0.0001223764,0.0002065172,0.0002585527,0.0000235913,0.0001336358,0.0002280695,0.000004491971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001271273,"about_ca_system_score_gemma":0.00005079003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003291378,"about_ca_topic_score_gemma":0.0005355999,"domain_scores_codex":[0.9981035,0.00007001789,0.0005856574,0.0004807751,0.0002138333,0.0005462281],"domain_scores_gemma":[0.9990129,0.00002934247,0.0001732688,0.0005542827,0.0001033039,0.000126863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000722256,0.0002014026,0.003571126,0.0000981662,0.00008430085,5.321205e-7,0.003446075,0.00001884218,0.9870493,0.00002534241,0.00125666,0.003526019],"study_design_scores_gemma":[0.005273518,0.0001510343,0.04628804,0.00004243348,0.00009282702,0.00001765252,0.0002660814,0.00004058357,0.9026266,0.000208052,0.04466974,0.0003234822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913827,0.005896151,0.0003765408,0.0004137923,0.0009310603,0.000717982,0.0001670197,0.00002108342,0.00009365821],"genre_scores_gemma":[0.9916285,0.005553114,0.00007926288,0.0009460699,0.001170637,0.00004159713,0.0001417103,0.00005137895,0.0003876752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08442273,"threshold_uncertainty_score":0.9882032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008422310943463374,"score_gpt":0.2493042450183165,"score_spread":0.2408819340748531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}