{"id":"W1971972260","doi":"10.1002/pros.20674","title":"Androgen‐mediated cholesterol metabolism in LNCaP and PC‐3 cell lines is regulated through two different isoforms of acyl‐coenzyme A: Cholesterol Acyltransferase (ACAT)","year":2007,"lang":"en","type":"article","venue":"The Prostate","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"National Cancer Institute; Terry Fox Foundation; Michael Smith Health Research BC; VGH and UBC Hospital Foundation","keywords":"LNCaP; Sterol O-acyltransferase; Endocrinology; Internal medicine; Androgen; Androgen receptor; Cholesterol; Reductase; Biology; Prostate cancer; Chemistry; Medicine; Enzyme; Biochemistry; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001475358,0.0003361352,0.0002788393,0.0004220949,0.0003121911,0.0004324989,0.0001960428,0.0001798173,0.001342206],"category_scores_gemma":[0.00009927052,0.0001619247,0.0004463564,0.0004163635,0.000268916,0.0001778362,0.0001549695,0.0004507753,0.0006375226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004238272,"about_ca_system_score_gemma":0.000444655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004798718,"about_ca_topic_score_gemma":0.007695464,"domain_scores_codex":[0.9997986,0.00002166203,0.00001657341,0.00004215601,0.00008399754,0.00003702731],"domain_scores_gemma":[0.9999084,0.00001450939,0.00002119117,0.00001325739,0.00002267987,0.00001994183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002899425,0.00006216223,0.001133587,0.00004930388,0.00001342276,0.00009968105,0.00002506496,0.00004613931,0.9961721,0.00006388123,0.00008347016,0.001961113],"study_design_scores_gemma":[0.00002271963,0.0005086169,0.02424517,0.000005080498,0.00006041719,0.000628728,0.00006322545,0.0004160353,0.9699439,0.00003482625,0.004060538,0.00001078241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884862,0.003790174,0.00302989,0.0001763623,0.00005396708,0.00004797419,0.001780652,0.0001469789,0.002487817],"genre_scores_gemma":[0.9808838,0.003602432,0.003645702,0.00009061799,0.00003283882,0.00008984627,0.003835147,0.00003528047,0.007784307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004798718,"threshold_uncertainty_score":0.009541571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008422310943463374,"score_gpt":0.2493042450183165,"score_spread":0.2408819340748531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}