{"id":"W1971973909","doi":"10.1002/jps.23639","title":"A Pulsed Tangential-Flow Ultrafiltration Technique for Studying Protein-Drug Binding","year":2013,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Protein purification and stability","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canada Research Chairs; McMaster University","keywords":"Ultrafiltration (renal); Chemistry; Drug; Flow (mathematics); Chromatography; Biophysics; Materials science; Mechanics; Pharmacology; Physics; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004792556,0.00044021,0.0004101248,0.0003442941,0.0005080448,0.0004618787,0.0007731746,0.0004422505,0.0006224506],"category_scores_gemma":[0.0003323615,0.0002376072,0.0003440816,0.0005577195,0.0003214874,0.0005559262,0.0002668486,0.001625136,0.00043687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005391141,"about_ca_system_score_gemma":0.0006588036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001433807,"about_ca_topic_score_gemma":0.001752794,"domain_scores_codex":[0.99983,0.00003264496,0.0000103143,0.00003267334,0.00007523411,0.00001908372],"domain_scores_gemma":[0.9997768,0.0000784207,0.00003041003,0.00003570816,0.00005575415,0.00002294866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005057075,0.00001539435,0.00005389516,0.00002483353,0.000005226132,0.00001115542,0.000009318499,0.00002973817,0.9970836,0.0001519127,0.00005676585,0.002507623],"study_design_scores_gemma":[0.00001655662,0.0001309631,0.001409217,0.000004088724,0.00002363592,0.0002357079,0.000009285412,0.002449244,0.9936532,0.000137883,0.001921752,0.000008375384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.6301497,0.006853301,0.3580378,0.0005039593,0.0002101049,0.0002007265,0.0008838744,0.00069687,0.002463762],"genre_scores_gemma":[0.7961741,0.00654524,0.1892944,0.0002501316,0.0000603177,0.0002165125,0.001660828,0.0001551014,0.005643415],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001433807,"threshold_uncertainty_score":0.003911555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04951527870832809,"score_gpt":0.3543427117588107,"score_spread":0.3048274330504825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}