{"id":"W1972003357","doi":"10.1002/pros.21178","title":"Immunohistochemical examination of the mTORC1 pathway in high grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinomas (PCa): A tissue microarray study (TMA)","year":2010,"lang":"en","type":"article","venue":"The Prostate","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Partnership Against Cancer; University Health Network","funders":"","keywords":"PI3K/AKT/mTOR pathway; P70-S6 Kinase 1; mTORC1; Tissue microarray; Cancer research; Immunohistochemistry; Ribosomal protein s6; Prostate cancer; Biology; Prostate; Cancer; Pathology; Medicine; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007045505,0.0002567865,0.0002436801,0.00005203791,0.0001289462,0.00004137017,0.0004354255,0.0001340737,0.00001058241],"category_scores_gemma":[0.0001999907,0.0001705797,0.00004731031,0.0001947089,0.0004688379,0.00001146511,0.0002215915,0.0004229667,0.000003268475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000392888,"about_ca_system_score_gemma":0.000178914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001860268,"about_ca_topic_score_gemma":0.0002561397,"domain_scores_codex":[0.9982311,0.0002774677,0.0004438779,0.0004438224,0.0002668516,0.000336891],"domain_scores_gemma":[0.9988614,0.00006438397,0.0002544278,0.0006602439,0.0001039869,0.00005557245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001666366,0.0002123571,0.009511169,0.00006918235,0.0000365497,0.000003994009,0.005072209,0.00001381311,0.9818745,0.00006506593,0.00004961375,0.002924952],"study_design_scores_gemma":[0.001789437,0.0007507745,0.07973103,0.00004965646,0.00004023407,0.00003918228,0.0005936851,0.0000446843,0.9157162,0.000457948,0.0005387085,0.0002484138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966943,0.0004553559,0.00003793143,0.0003237223,0.0003101304,0.002054906,0.00006702311,0.00001328242,0.00004335604],"genre_scores_gemma":[0.9988163,0.00001922937,0.0002815706,0.00007446176,0.0001036142,0.0002868536,0.00003377878,0.00004469639,0.0003394767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07021986,"threshold_uncertainty_score":0.6956037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005793607398408068,"score_gpt":0.2333769374710588,"score_spread":0.2275833300726507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}