{"id":"W1972003357","doi":"10.1002/pros.21178","title":"Immunohistochemical examination of the mTORC1 pathway in high grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinomas (PCa): A tissue microarray study (TMA)","year":2010,"lang":"en","type":"article","venue":"The Prostate","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Partnership Against Cancer; University Health Network","funders":"","keywords":"PI3K/AKT/mTOR pathway; P70-S6 Kinase 1; mTORC1; Tissue microarray; Cancer research; Immunohistochemistry; Ribosomal protein s6; Prostate cancer; Biology; Prostate; Cancer; Pathology; Medicine; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002853519,0.0001566268,0.0002294292,0.0009946328,0.0003266665,0.0002329643,0.0001616412,0.0002508572,0.001093914],"category_scores_gemma":[0.0002055757,0.0001549855,0.0002192239,0.000971118,0.0001527641,0.0001805329,0.0002086836,0.0002086353,0.00030509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001739784,"about_ca_system_score_gemma":0.0002014622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007472542,"about_ca_topic_score_gemma":0.001592758,"domain_scores_codex":[0.9997333,0.00003336484,0.00003080762,0.00007378314,0.0000785586,0.00005018706],"domain_scores_gemma":[0.9998246,0.00003299024,0.00004031016,0.00002375896,0.00005048303,0.00002789486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005543982,0.00009397758,0.05895355,0.0001946308,0.00007407417,0.000796914,0.0001632828,0.0001520569,0.9265359,0.0001115744,0.0003326975,0.01203693],"study_design_scores_gemma":[0.00001911952,0.001081555,0.794592,0.00002105772,0.0002576624,0.01220531,0.0007445425,0.00271628,0.1809074,0.0001244968,0.007310971,0.00001966194],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916181,0.001132887,0.004302929,0.00005703638,0.0000235418,0.00008479396,0.001165872,0.0001056494,0.001509254],"genre_scores_gemma":[0.986805,0.0007224326,0.009005922,0.00004868527,0.00002101758,0.0001729742,0.00189062,0.00001428054,0.001319026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001093914,"threshold_uncertainty_score":0.003659546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005793607398408068,"score_gpt":0.2333769374710588,"score_spread":0.2275833300726507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}