{"id":"W1972005136","doi":"10.1074/jbc.m111.273730","title":"Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":219,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Structural Genomics Consortium; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; Wellcome Trust","keywords":"Aggresome; HDAC6; Ubiquitin; Cell biology; Deubiquitinating enzyme; Chemistry; Protein aggregation; Dynein; Chaperone (clinical); Histone deacetylase; Biology; Biochemistry; Microtubule; Histone; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000406928,0.0003080963,0.0004189682,0.0000374257,0.00007768548,0.00002115852,0.0005476846,0.0004719262,0.0003327101],"category_scores_gemma":[0.000577379,0.000233363,0.0002469451,0.0001392673,0.0001648782,0.000007470958,0.0001833137,0.0003454016,0.00002053713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004888406,"about_ca_system_score_gemma":0.00007092828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005768356,"about_ca_topic_score_gemma":9.374687e-7,"domain_scores_codex":[0.9982518,0.00009688494,0.0006350357,0.0003945753,0.0001987954,0.0004228955],"domain_scores_gemma":[0.998279,0.00001790758,0.0007074665,0.0003339779,0.0002371328,0.0004245587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006182802,0.0002402541,0.0006403767,0.00003928354,0.00005361589,0.00009325076,0.00004910594,3.751175e-7,0.9904243,0.000001611597,0.00279182,0.005047749],"study_design_scores_gemma":[0.0006509001,0.0009420894,0.0005047511,0.0001509337,0.00001599222,0.000276284,0.00007269604,0.000001256278,0.9697524,0.0001549715,0.02715424,0.0003234578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994202,0.003676163,0.000306315,0.0002102594,0.00007710332,0.0002605772,0.00007108416,0.0000201493,0.001176324],"genre_scores_gemma":[0.9953604,0.0002108859,0.002402839,0.0004379442,0.0004451171,0.00004243974,0.00005937552,0.00002737721,0.001013658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02436242,"threshold_uncertainty_score":0.9516268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0335602231619163,"score_gpt":0.2615824639595613,"score_spread":0.2280222407976449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}