{"id":"W1972021734","doi":"10.1074/jbc.m109.096958","title":"DNA Binding by the ETS Protein TEL (ETV6) Is Regulated by Autoinhibition and Self-association","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research","keywords":"Cooperativity; DNA; Cooperative binding; Chemistry; DNA-binding domain; Repressor; Binding site; Conformational change; Binding domain; Electrophoretic mobility shift assay; Biophysics; DNA-binding protein; Dimer; Stereochemistry; Biochemistry; Molecular biology; Transcription factor; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009951523,0.0001967681,0.0001709378,0.0001223133,0.0001122521,0.0003777344,0.0001924878,0.0001581858,0.001018319],"category_scores_gemma":[0.0001719661,0.0001436645,0.000136086,0.0000959495,0.0001786831,0.000174214,0.0003651227,0.0002656451,0.0006061355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002730424,"about_ca_system_score_gemma":0.00007047025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002634422,"about_ca_topic_score_gemma":0.0004193865,"domain_scores_codex":[0.9998554,0.00002348598,0.00001102047,0.00003539286,0.00004834218,0.00002634121],"domain_scores_gemma":[0.9997913,0.00004138669,0.00008227494,0.00001473767,0.00002647054,0.00004386875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006464431,0.00002070848,0.001080699,0.0000158546,0.000003415388,0.00003149437,0.0000116321,0.00007451785,0.9972515,0.00006996333,0.00003023125,0.001345241],"study_design_scores_gemma":[0.00001508275,0.0001639588,0.04532023,0.000008137557,0.0000114777,0.000609833,0.00006142413,0.004783863,0.946543,0.000157647,0.002317369,0.000007894332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966215,0.001057049,0.001577089,0.00003059421,0.000005336256,0.000003309107,0.00004660817,0.00007213165,0.0005863367],"genre_scores_gemma":[0.9969286,0.0003666007,0.0007447927,0.00002359675,0.000004371693,0.000006911454,0.000206658,0.00002305543,0.001695454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001018319,"threshold_uncertainty_score":0.003406584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004635212439357705,"score_gpt":0.2147385720157718,"score_spread":0.2101033595764141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}