{"id":"W1972022583","doi":"10.1021/jm010097f","title":"<i>N</i>-Aryl Sulfonyl Homocysteine Hydroxamate Inhibitors of Matrix Metalloproteinases:  Further Probing of the S<sub>1</sub>, S<sub>1</sub>‘, and S<sub>2</sub>‘ Pockets","year":2001,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Hydroxamic acid; Sulfonyl; Aryl; Matrix metalloproteinase; Stereochemistry; Alkyl; Enzyme; Homocysteine; Enzyme inhibitor; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002150624,0.0003438416,0.0002313452,0.0001373696,0.0001025462,0.0001307383,0.0001490912,0.0001691483,0.0007388189],"category_scores_gemma":[0.0001761914,0.0001105754,0.0001578305,0.0001232396,0.0001587355,0.0001477312,0.00009983288,0.0002607327,0.0001965916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001618238,"about_ca_system_score_gemma":0.0001969614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003602839,"about_ca_topic_score_gemma":0.001360184,"domain_scores_codex":[0.9999098,0.00003010536,0.000007647086,0.000009100074,0.00002379841,0.00001950327],"domain_scores_gemma":[0.9999292,0.00001391669,0.00002113288,0.000005403256,0.00001442632,0.00001595617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003772529,0.00006740311,0.0002117064,0.00009628769,0.00001103524,0.0001099149,0.00002545146,0.0002316272,0.9918972,0.0002002415,0.0001354351,0.006636603],"study_design_scores_gemma":[0.0001148564,0.002153244,0.001481023,0.000007206449,0.00002513375,0.0004039203,0.00001535966,0.0005346434,0.9919664,0.00006349837,0.00322797,0.000006724123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847816,0.006027724,0.004715499,0.0001891836,0.00004850647,0.00009648834,0.0002189324,0.00005226415,0.00386985],"genre_scores_gemma":[0.9866284,0.003797832,0.006987087,0.0001270281,0.00003233294,0.0000657406,0.000242793,0.000008066517,0.002110632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007388189,"threshold_uncertainty_score":0.002471626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00725771422247384,"score_gpt":0.2304929526570751,"score_spread":0.2232352384346012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}