{"id":"W1972023043","doi":"10.1371/journal.pgen.1003124","title":"WNK1/HSN2 Mutation in Human Peripheral Neuropathy Deregulates KCC2 Expression and Posterior Lateral Line Development in Zebrafish (Danio rerio)","year":2013,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Zebrafish; Biology; Morpholino; Gene knockdown; Cell biology; Phenocopy; Molecular biology; Phenotype; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000568411,0.0001658363,0.000138165,0.0000727575,0.00005622944,0.00004219621,0.00008333315,0.0001456269,0.00003315825],"category_scores_gemma":[0.000006288441,0.0001652241,0.0000232169,0.00006706987,0.00003700699,0.00001156972,0.00005138365,0.00007482885,0.000002926144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001838424,"about_ca_system_score_gemma":0.00002648729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001405092,"about_ca_topic_score_gemma":0.0001857627,"domain_scores_codex":[0.9989819,0.00004357247,0.0003275868,0.000306926,0.0001174565,0.000222558],"domain_scores_gemma":[0.9996693,0.00000309816,0.00006275657,0.0001431294,0.00006022691,0.00006149477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000281863,0.0000755868,0.03962218,0.00003214337,0.000005086968,0.000007078816,0.0006398599,0.0002719409,0.9581133,0.00000132514,0.00001370141,0.001189651],"study_design_scores_gemma":[0.0007216295,0.0001559651,0.2687817,0.00005110294,0.000004160614,0.000007895677,0.0000668811,0.001591798,0.7282266,0.00005120215,0.0001531275,0.0001879245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991477,0.0003067146,0.00004999043,0.00007857859,0.0000599447,0.0003118179,0.000002371655,0.00001163558,0.00003124489],"genre_scores_gemma":[0.9985133,0.00003281893,0.0007815397,0.0001132429,0.00009397538,0.00004536402,0.000258154,0.00002869576,0.0001328563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2298867,"threshold_uncertainty_score":0.6737645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00994580258858267,"score_gpt":0.2157004105825349,"score_spread":0.2057546079939522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}