{"id":"W1972029787","doi":"10.1038/nrd4228","title":"Advances in targeting cyclic nucleotide phosphodiesterases","year":2014,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":769,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Cyclic nucleotide; Phosphodiesterase; Cyclic nucleotide phosphodiesterase; Nucleotide; Compartmentalization (fire protection); cGMP-specific phosphodiesterase type 5; Signalling; Pharmacology; Signal transduction; Biology; Intracellular; Medicine; Cell biology; Biochemistry; Erectile dysfunction; Enzyme; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009515156501613995,"score_gpt":0.3152611343199794,"score_spread":0.3057459778183654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}