{"id":"W1972030393","doi":"10.1007/s12010-009-8657-1","title":"Generation of a Recombinant Full-Length Human Antibody Binding to Botulinum Neurotoxin A","year":2009,"lang":"en","type":"article","venue":"Applied Biochemistry and Biotechnology","topic":"Botulinum Toxin and Related Neurological Disorders","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ag-West Bio (Canada); Aptose Biosciences (Canada); Defence Research and Development Canada","funders":"","keywords":"Molecular biology; Recombinant DNA; Immunoglobulin light chain; Antibody; Biology; Antigen; Epitope; Peptide library; Humanized antibody; Monoclonal antibody; Expression vector; Phage display; Escherichia coli; Virology; Gene; Peptide sequence; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008159084,0.0001767029,0.0003077471,0.0001098015,0.0000906174,0.000007382321,0.0001067047,0.0006903226,0.00001980074],"category_scores_gemma":[0.00003696035,0.0001412541,0.00005379365,0.0003384,0.0001577281,0.00001009018,0.00005652188,0.0003973564,0.000008321304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001126198,"about_ca_system_score_gemma":0.00001667474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001508661,"about_ca_topic_score_gemma":3.425448e-7,"domain_scores_codex":[0.9989192,0.000008796986,0.000288261,0.000434565,0.00009474444,0.0002544685],"domain_scores_gemma":[0.9995014,0.00001169025,0.0000871127,0.0002749913,0.00002063066,0.0001041643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001402807,0.0002295114,0.00005534443,0.00003342637,0.00001871915,0.00002176213,0.00001278058,9.722343e-7,0.9874666,0.001358123,0.0002501344,0.01041236],"study_design_scores_gemma":[0.0009794738,0.001159036,0.0005148009,0.0000271408,0.00004027536,0.0001177658,0.00004490415,0.0000655012,0.9956173,0.0004100822,0.0008686675,0.0001550111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903972,0.00009619062,0.0001042758,0.007965302,0.0000471067,0.0004553967,0.000002808482,0.0001348271,0.000796943],"genre_scores_gemma":[0.997927,0.0002657462,0.0005851861,0.0009758344,0.00004222745,0.00001750273,0.00004771386,0.000009349585,0.000129498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01025735,"threshold_uncertainty_score":0.5760173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02198825545448254,"score_gpt":0.2837082513784666,"score_spread":0.261719995923984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}